PAX5

Paired box protein Pax-5 ;
B-cell-specific transcription factor ;
BSAP ;

developmental stage:Expressed at early B-cell differentiation, in the developing CNS and in adult testis.,disease:A chromosomal aberration involving PAX5 is a cause of acute lymphoblastic leukemia. Translocation t(9;18)(p13;q11.2) with ZNF521. Translocation t(9;3)(p13;p14.1) with FOXP1. Translocation t(9;12)(p13;p13) with ETV6.,function:May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene.,PTM:O-glycosylated.,similarity:Contains 1 paired domain.,subunit:Interacts with DAXX (By similarity). Binds DNA as a monomer. Binds TLE4.,

negative regulation of transcription from RNA polymerase II promoter, transcription, transcription, DNA-dependent,regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter, immune response, humoral immune response, gamete generation,spermatogenesis, negative regulation of biosynthetic process, negative regulation of macromolecule biosynthetic process, negative regulation of macromolecule metabolic process, negative regulation of gene expression, negative regulation of organelle organization, negative regulation of transcription, sexual reproduction, regulation of histone modification, negative regulation of histone modification, regulation of histone methylation, negative regulation of histone methylation, negative regulation of cellular biosynthetic process, regulation of protein modification process,negative regulation of protein modification process, regulation of cellular protein metabolic process, negative regulation of cellular protein metabolic process, multicellular organism reproduction, RNA biosynthetic process,regulation of organelle organization, regulation of chromosome organization, regulation of transcription, negative regulation of transcription, DNA-dependent, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, male gamete generation, reproductive process in a multicellular organism, negative regulation of cellular component organization, negative regulation of nitrogen compound metabolic process, negative regulation of protein metabolic process, regulation of RNA metabolic process, negative regulation of RNA metabolic process,regulation of histone H3-K9 methylation, negative regulation of histone H3-K9 methylation,

Nucleus .