caution:Was originally (PubMed:12819012) thought to one of the key factors that controls the specialized post-capillary high endothelial venules (HEV) phenotype found in organized secondary lymphoid tissue and to be nuclear localized. ,function:Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88 , IRAK1 , IRAK4 , and TRAF6 , followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2 , MAPK14 , and MAPK8. Induces T helper type 2-associated cytokines. ,PTM:Proteolytically converted to a mature form by CASP1. ,similarity:Belongs to the IL-1 family. Highly divergent. ,tissue specificity:Expressed at high level in high endothelial venules found in tonsils , Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta. ,
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