Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

IL21

Interleukin-21

IL21 ;
Interleukin-21 ;
IL-21 ;
Za11

function:Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG (1) and IgG (3) in B-cells (By similarity) . May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. ,similarity:Belongs to the IL-15/IL-21 family. ,tissue specificity:Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells , B-cells , or monocytes. ,

regulation of cytokine production , positive regulation of cytokine production , regulation of leukocyte mediated cytotoxicity , positive regulation of leukocyte mediated cytotoxicity , positive regulation of immune system process ,regulation of leukocyte activation , positive regulation of leukocyte activation , regulation of immune effector process ,positive regulation of immune effector process , regulation of production of molecular mediator of immune response ,positive regulation of production of molecular mediator of immune response , regulation of leukocyte mediated immunity , positive regulation of leukocyte mediated immunity , regulation of lymphocyte mediated immunity , positive regulation of lymphocyte mediated immunity , regulation of natural killer cell mediated immunity , positive regulation of natural killer cell mediated immunity , regulation of cytokine production during immune response , positive regulation of cytokine production during immune response , regulation of natural killer cell cytokine production , positive regulation of natural killer cell cytokine production , positive regulation of cell proliferation , positive regulation of biosynthetic process , positive regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , developmental maturation , positive regulation of cellular biosynthetic process , regulation of cell killing ,positive regulation of cell killing , positive regulation of defense response , regulation of interferon-gamma production ,regulation of interleukin-10 production , positive regulation of interleukin-10 production , regulation of natural killer cell activation , positive regulation of natural killer cell activation , regulation of natural killer cell differentiation , positive regulation of natural killer cell differentiation , regulation of mononuclear cell proliferation , positive regulation of mononuclear cell proliferation , regulation of cytokine biosynthetic process , positive regulation of T cell proliferation ,positive regulation of cytokine biosynthetic process , regulation of cell proliferation , regulation of T cell proliferation ,regulation of natural killer cell mediated cytotoxicity , regulation of interferon-gamma biosynthetic process , positive regulation of interferon-gamma biosynthetic process , regulation of innate immune response , positive regulation of innate immune response , positive regulation of cell differentiation , regulation of lymphocyte differentiation , positive regulation of lymphocyte differentiation , positive regulation of natural killer cell mediated cytotoxicity , cell maturation ,positive regulation of response to stimulus , regulation of lymphocyte proliferation , positive regulation of lymphocyte proliferation , positive regulation of immune response , regulation of T cell activation , regulation of cell activation ,positive regulation of cell activation , positive regulation of T cell activation , positive regulation of developmental process , positive regulation of multicellular organismal process , regulation of lymphocyte activation , positive regulation of lymphocyte activation , regulation of leukocyte proliferation , positive regulation of leukocyte proliferation ,

Secreted .