Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

IL1A

Interleukin-1 alpha

IL1A ;
IL1F1 ;
Interleukin-1 alpha ;
IL-1 alpha ;
Hematopoietin-1

domain:The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function. ,function:Produced by activated macrophages , IL-1 stimulates thymocyte proliferation by inducing IL-2 release , B-cell maturation and proliferation , and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response , being identified as endogenous pyrogens , and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. ,online information:Interleukin-1 entry ,online information:The Singapore human mutation and polymorphism database ,similarity:Belongs to the IL-1 family. ,subcellular location:The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. ,subunit:Monomer. ,

temperature homeostasis , fever , regulation of cytokine production , positive regulation of cytokine production , acute inflammatory response , apoptosis , anti-apoptosis , defense response , acute-phase response , inflammatory response ,immune response , regulation of mitosis , regulation of mitotic cell cycle , cell death , cell proliferation , negative regulation of cell proliferation , response to wounding , positive regulation of biosynthetic process , positive regulation of macromolecule biosynthetic process , regulation of cell cycle process , regulation of vascular endothelial growth factor production , positive regulation vascular endothelial growth factor production , positive regulation of macromolecule metabolic process , positive regulation of organelle organization , regulation of cell death , programmed cell death ,death , cytokine-mediated signaling pathway , positive regulation of cellular biosynthetic process , heat generation ,regulation of interleukin-2 production , regulation of protein localization , regulation of organelle organization ,regulation of cytokine biosynthetic process , positive regulation of cytokine biosynthetic process , regulation of cell proliferation , homeostatic process , regulation of apoptosis , negative regulation of apoptosis , regulation of programmed cell death , negative regulation of programmed cell death , regulation of interleukin-2 biosynthetic process , positive regulation of interleukin-2 biosynthetic process , regulation of angiogenesis , positive regulation of angiogenesis , positive regulation of cell cycle , positive regulation of mitosis , multicellular organismal homeostasis ,regulation of cytokine secretion , regulation of protein secretion , positive regulation of protein secretion , positive regulation of cytokine secretion , regulation of secretion , positive regulation of secretion , positive regulation of transport , positive regulation of developmental process , positive regulation of cellular component organization ,positive regulation of protein transport , regulation of protein transport , positive regulation of multicellular organismal process , regulation of cell division , regulation of cell cycle , positive regulation of cell division , regulation of nuclear division , positive regulation of nuclear division , regulation of cellular localization , negative regulation of cell death ,regulation of establishment of protein localization ,

Cytoplasm . Secreted . The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059) . .