CDKN2B

Cyclin-dependent kinase 4 inhibitor B ;
Multiple tumor suppressor 2 ;
MTS-2 ;
p14-INK4b ;
p15-INK4b ;
p15INK4B ;

disease:Defects in CDKN2B are involved in tumor formation.,function:Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.,polymorphism:Genetic variations in CDKN2B may underlie susceptibility to uveal melanoma [MIM:155720]. Uveal melanoma is the most common type of ocular malignant tumor, consisting of overgrowth of uveal melanocytes and often preceded by a uveal nevus.,similarity:Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.,similarity:Contains 4 ANK repeats.,subunit:Heterodimer of CDKN2B with CDK4 or CDK6.,

cell cycle checkpoint, regulation of cyclin-dependent protein kinase activity, G2/M transition of mitotic cell cycle, mitotic cell cycle, cell cycle, cell cycle arrest, mitotic cell cycle checkpoint, regulation of mitotic cell cycle, response to nutrient,negative regulation of cell proliferation, positive regulation of signal transduction, response to extracellular stimulus,response to organic substance, negative regulation of phosphorus metabolic process, positive regulation of cell communication, response to organic cyclic substance, regulation of transforming growth factor beta receptor signaling pathway, regulation of phosphate metabolic process, cell cycle process, cell cycle phase, positive regulation of transforming growth factor beta receptor signaling pathway, regulation of epithelial cell differentiation, positive regulation of epithelial cell differentiation, G1/S transition checkpoint, response to nutrient levels, cellular response to extracellular stimulus, cellular response to nutrient levels, cellular response to nutrient, response to cytokine stimulus,regulation of cell proliferation, regulation of phosphorylation, negative regulation of phosphorylation, regulation of kinase activity, positive regulation of cell differentiation, regulation of protein kinase activity, negative regulation of phosphate metabolic process, regulation of epithelial cell proliferation, negative regulation of epithelial cell proliferation, positive regulation of developmental process, regulation of phosphorus metabolic process, interphase,interphase of mitotic cell cycle, regulation of transferase activity, regulation of cell cycle,

Cytoplasm . Also found in the nucleus.

Isoform 2 is expressed in normal (keratinocytes, fibroblasts) and tumor cell lines.