function:Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine , which , in vitro , suppresses hematopoietic progenitor cell proliferation. GRO-beta (5-73) shows a highly enhanced hematopoietic activity. ,online information:CXCL2 entry ,pharmaceutical:GRO-beta (5-73) is available under the name Garnocestim as immunomodulator. It is used prior to hematopoietic transplantation for peripheral blood stem cell mobilization and reduction of incidence , duration , and/or severity of chemotherapy induced cytopenias. ,PTM:The N-terminal processed form GRO-beta (5-73) is produced by proteolytic cleavage after secretion from bone marrow stromal cells. ,similarity:Belongs to the intercrine alpha (chemokine CxC) family. ,
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