SPP1

Osteopontin ;
Bone sialoprotein 1 ;
Nephropontin ;
Secreted phosphoprotein 1 ;
SPP-1 ;
Urinary stone protein ;
Uropontin ;

disease:This protein plays a principal role in urinary stone formation as the stone matrix.,function:Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.,function:Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.,online information:Osteopontin entry,PTM:Extensively phosphorylated on clustered serine residues.,PTM:N- and O-glycosylated.,similarity:Belongs to the osteopontin family.,subunit:Ligand for integrin alpha-V/beta-3.,

skeletal system development, ossification, regulation of cell growth, osteoblast differentiation, placenta development,maternal placenta development, reproductive developmental process, defense response, inflammatory response, cell adhesion, female pregnancy, embryo implantation, response to nutrient, regulation of cell size, response to wounding,response to endogenous stimulus, response to hormone stimulus, response to extracellular stimulus, response to organic substance, negative regulation of cell development, regulation of cell morphogenesis involved in differentiation, regulation of cell-substrate adhesion, positive regulation of cell-substrate adhesion, regulation of neuron projection development, negative regulation of neuron projection development, regulation of cell morphogenesis, biological adhesion, regulation of cell adhesion, negative regulation of cell growth, biomineral formation, regulation of cell projection organization, negative regulation of cell projection organization, response to nutrient levels, regulation of response to external stimulus, negative regulation of response to external stimulus,regulation of cellular component size, regulation of homeostatic process, positive regulation of homeostatic process,response to vitamin, response to vitamin D, regulation of tissue remodeling, positive regulation of tissue remodeling,regulation of growth, regulation of bone resorption, negative regulation of cell differentiation, regulation of neuron differentiation, positive regulation of bone resorption, positive regulation of cell adhesion, negative regulation of cell size, negative regulation of growth, decidualization, regulation of bone remodeling, positive regulation of bone remodeling, response to steroid hormone stimulus, negative regulation of response to stimulus, regulation of developmental growth, negative regulation of developmental growth, regulation of collateral sprouting, negative regulation of collateral sprouting, regulation of axon regeneration, negative regulation of axon regeneration,regulation of collateral sprouting of intact axon in response to injury, negative regulation of collateral sprouting of intact axon in response to injury, regulation of neurogenesis, negative regulation of neurogenesis, regulation of axonogenesis, negative regulation of axonogenesis, negative regulation of cellular component organization, positive regulation of multicellular organismal process, regulation of nervous system development, regulation of cell development, bone development, regulation of neuron projection regeneration, negative regulation of neuron projection regeneration, regulation of cellular response to stress,

Secreted.

Bone. Found in plasma.