Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

CSF2

Granulocyte-macrophage colony-stimulating factor

CSF2 ;
GMCSF ;
Granulocyte-macrophage colony-stimulating factor ;
GM-CSF ;
Colony-stimulating factor ;
CSF ;
Molgramostin ;
Sargramostim

function:Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages , including granulocytes , macrophages , eosinophils and erythrocytes. ,online information:Clinical information on Leukine ,pharmaceutical:Available under the names Leukine (Immunex) and Leucomax (Novartis) . Used in myeloid reconstitution following bone marrow transplant , bone marrow transplant engraftment failure or delay , mobilization and following transplantation of autologous peripheral blood progenitor cells , and following induction chemotherapy in older adults with acute myelogenous leukemia. ,polymorphism:Variant Ile-117 may be a risk factor for atopic asthma. ,similarity:Belongs to the GM-CSF family. ,subunit:Monomer. ,

myeloid dendritic cell activation , cell activation , regulation of protein amino acid phosphorylation , positive regulation of protein amino acid phosphorylation , myeloid leukocyte activation , immune system development , leukocyte differentiation , myeloid leukocyte differentiation , regulation of DNA replication , anti-apoptosis , immune response ,positive regulation of cell proliferation , positive regulation of biosynthetic process , positive regulation of signal transduction , positive regulation of macromolecule biosynthetic process , positive regulation of phosphorus metabolic process , positive regulation of macromolecule metabolic process , regulation of protein kinase cascade , positive regulation of gene expression , positive regulation of cell communication , positive regulation of protein kinase cascade ,regulation of foam cell differentiation , positive regulation of foam cell differentiation , regulation of cell death , regulation of phosphate metabolic process , hemopoiesis , myeloid cell differentiation , positive regulation of cellular biosynthetic process , regulation of protein modification process , positive regulation of protein modification process , regulation of cellular protein metabolic process , positive regulation of cellular protein metabolic process , fluid transport , epithelial fluid transport , regulation of cell proliferation , regulation of cytolysis , regulation of phosphorylation , positive regulation of phosphorylation , regulation of tyrosine phosphorylation of STAT protein , regulation of tyrosine phosphorylation of Stat5 protein , positive regulation of tyrosine phosphorylation of Stat5 protein , positive regulation of tyrosine phosphorylation of STAT protein , regulation of apoptosis , myeloid dendritic cell differentiation , negative regulation of apoptosis , regulation of programmed cell death , negative regulation of programmed cell death , leukocyte activation ,positive regulation of cell differentiation , positive regulation of DNA replication , regulation of survival gene product expression , positive regulation of survival gene product expression , negative regulation of cytolysis , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of phosphate metabolic process , regulation of JAK-STAT cascade , positive regulation of JAK-STAT cascade , hemopoietic or lymphoid organ development , regulation of peptidyl-tyrosine phosphorylation , positive regulation of peptidyl-tyrosine phosphorylation , regulation of DNA metabolic process , positive regulation of DNA metabolic process , positive regulation of developmental process , positive regulation of nitrogen compound metabolic process , regulation of phosphorus metabolic process , positive regulation of protein metabolic process , negative regulation of cell death ,

Secreted .