NME2

Nucleoside diphosphate kinase B ;
NDK B ;
NDP kinase B ;
C-myc purine-binding transcription factor PUF ;
Histidine protein kinase NDKB ;
nm23-H2 ;

catalytic activity:ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.,cofactor:Magnesium.,disease:This protein is found in reduced amount in tumor cells of high metastatic potential.,disease:This protein is found in reduced amount in tumor cells of high metastatic potential. Somatic mutations of NME1 are found in neuroblastoma. Increased NME1 in neuroblastoma is correlated with features of the disease that are associated with aggressive tumors. May therefore have distinct if not opposite roles in different tumors.,enzyme regulation:Autophosphorylation at His-118 increases serine/threonine protein kinase activity of the enzyme. Interaction with the SET complex inhibits exonuclease activity.,function:Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the c-Myc gene; binds DNA non-specifically (PubMed:8392752).,function:Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. Has tumor metastasis-suppressive capacity.,PTM:The N-terminus is blocked.,similarity:Belongs to the NDK family.,subcellular location:Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA.,subcellular location:Isoform 2 is mainly cytoplasmic and isoform 1 and isoform 2 are excluded from the nucleolus.,subunit:Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). Interacts with CAPN8 (By similarity). Interacts with AKAP13.,subunit:Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). Interacts with SET and PRUNE.,tissue specificity:Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation. Isoform 3 is ubiquitously expressed.,tissue specificity:Ubiquitously expressed.,

regulation of myeloid leukocyte differentiation, negative regulation of myeloid leukocyte differentiation, purine nucleotide metabolic process, purine nucleotide biosynthetic process, nucleoside diphosphate phosphorylation, GTP biosynthetic process, pyrimidine nucleoside metabolic process, pyrimidine nucleotide metabolic process, pyrimidine nucleotide biosynthetic process, UTP biosynthetic process, CTP biosynthetic process, transcription, regulation of transcription, DNA-dependent, phosphorus metabolic process, phosphate metabolic process, endocytosis, cell adhesion, lactation, positive regulation of cell proliferation, negative regulation of cell proliferation, nucleoside metabolic process, ribonucleoside metabolic process, nucleoside diphosphate metabolic process, nucleoside triphosphate metabolic process, nucleoside triphosphate biosynthetic process, purine nucleoside triphosphate metabolic process, purine nucleoside triphosphate biosynthetic process, pyrimidine nucleoside triphosphate metabolic process, pyrimidine nucleoside triphosphate biosynthetic process, purine ribonucleotide metabolic process, purine ribonucleotide biosynthetic process, nucleotide biosynthetic process, ribonucleoside triphosphate metabolic process,ribonucleoside triphosphate biosynthetic process, purine ribonucleoside triphosphate metabolic process, purine ribonucleoside triphosphate biosynthetic process, pyrimidine ribonucleoside triphosphate metabolic process,pyrimidine ribonucleoside triphosphate biosynthetic process, pyrimidine ribonucleotide metabolic process, pyrimidine ribonucleotide biosynthetic process, ribonucleotide metabolic process, ribonucleotide biosynthetic process, response to organic substance, membrane invagination, regulation of cell death, membrane organization, vesicle-mediated transport, phosphorylation, biological adhesion, regulation of epithelial cell differentiation, positive regulation of epithelial cell differentiation, mammary gland development, multicellular organism reproduction, nucleobase, nucleoside and nucleotide biosynthetic process, nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process, regulation of cell proliferation, response to drug, regulation of apoptosis, negative regulation of apoptosis,regulation of programmed cell death, negative regulation of programmed cell death, positive regulation of DNA binding, positive regulation of molecular function, nitrogen compound biosynthetic process, regulation of transcription,negative regulation of cell differentiation, positive regulation of cell differentiation, regulation of epidermal cell differentiation, positive regulation of epidermal cell differentiation, regulation of keratinocyte differentiation, positive regulation of keratinocyte differentiation, regulation of myeloid cell differentiation, negative regulation of myeloid cell differentiation, regulation of epidermis development, positive regulation of epidermis development, CTP metabolic process, GTP metabolic process, UTP metabolic process, pyrimidine ribonucleoside metabolic process, nucleotide phosphorylation, reproductive process in a multicellular organism, gland development, regulation of epithelial cell proliferation, positive regulation of epithelial cell proliferation, positive regulation of developmental process, regulation of binding, positive regulation of binding, regulation of DNA binding, regulation of RNA metabolic process, response to cAMP, negative regulation of cell death,

Cytoplasm . Cell projection, lamellipodium . Cell projection, ruffle . Colocalizes with ITGB1 and ITGB1BP1 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen but not on vitronectin or laminin substrates. .; [Isoform 1]: Cytoplasm . Cytoplasm, perinuclear region . Nucleus .; [Isoform 3]: Cytoplasm . Cytoplasm, perinuclear region . Nucleus .

[Isoform 1]: Ubiquitously expressed. ; [Isoform 3]: Ubiquitously expressed.