NCK2

Cytoplasmic protein NCK2 ;
Growth factor receptor-bound protein 4 ;
NCK adaptor protein 2 ;
Nck-2 ;
SH2/SH3 adaptor protein NCK-beta ;

function:Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 SH3 domains.,similarity:Contains 3 SH3 domains.,subunit:Interacts with DOCK1, PINCH and TGFB1I1. Part of a complex containing PPP1R15B, PP1 and NCK2.,tissue specificity:Ubiquitous.,

cell activation, positive regulation of immune system process, regulation of leukocyte activation, positive regulation of leukocyte activation, regulation of translation, protein complex assembly, cell motion, cytoskeleton organization, actin filament organization, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway, signal complex assembly, epidermal growth factor receptor signaling pathway, regulation of epidermal growth factor receptor activity, regulation of actin polymerization or depolymerization, positive regulation of cell proliferation, negative regulation of cell proliferation,regulation of receptor activity, posttranscriptional regulation of gene expression, positive regulation of organelle organization, cell migration, regulation of phosphate metabolic process, actin filament-based process, cell projection organization, cell projection assembly, lamellipodium assembly, actin cytoskeleton organization, regulation of actin filament length, regulation of actin filament polymerization, positive regulation of actin filament polymerization, positive regulation of protein complex assembly, regulation of cellular protein metabolic process, regulation of protein polymerization, positive regulation of protein polymerization, regulation of cellular component size, regulation of mononuclear cell proliferation, positive regulation of mononuclear cell proliferation, regulation of actin cytoskeleton organization, regulation of actin filament-based process, regulation of organelle organization, cellular macromolecular complex subunit organization, cellular macromolecular complex assembly, regulation of epidermal growth factor receptor signaling pathway, positive regulation of T cell proliferation, T cell activation, regulation of cell proliferation,regulation of T cell proliferation, regulation of phosphorylation, regulation of protein complex assembly, regulation of kinase activity, cellular protein complex assembly, macromolecular complex subunit organization, regulation of cellular component biogenesis, leukocyte activation, regulation of protein kinase activity, lymphocyte activation, cell motility,regulation of lymphocyte proliferation, positive regulation of lymphocyte proliferation, regulation of T cell activation,regulation of cell activation, positive regulation of cell activation, positive regulation of T cell activation, positive regulation of cellular component organization, regulation of phosphorus metabolic process, regulation of lymphocyte activation, positive regulation of lymphocyte activation, regulation of transferase activity, regulation of cytoskeleton organization, positive regulation of cytoskeleton organization, localization of cell, macromolecular complex assembly,protein complex biogenesis, regulation of leukocyte proliferation, positive regulation of leukocyte proliferation,

Cytoplasm . Endoplasmic reticulum .

Ubiquitous.