MMP14

Matrix metalloproteinase-14 ;
MMP-14 ;
MMP-X1 ;
Membrane-type matrix metalloproteinase 1 ;
MT-MMP 1 ;
MTMMP1 ;
Membrane-type-1 matrix metalloproteinase ;
MT1-MMP ;
MT1MMP ;

catalytic activity:Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe-342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain.,cofactor:Binds 1 zinc ion per subunit.,cofactor:Calcium.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,function:Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,tissue specificity:In stromal cells of colon, breast, and head and neck.,

skeletal system development, ossification, angiogenesis, ovarian follicle development, blood vessel development,response to hypoxia, morphogenesis of a branching structure, endothelial cell proliferation, vasculature development,regulation of cell-matrix adhesion, negative regulation of cell-matrix adhesion, reproductive developmental process,proteolysis, cell motion, response to oxidative stress, negative regulation of cell adhesion, sex differentiation, cell proliferation, glial cell migration, gonad development, female gonad development, response to mechanical stimulus,response to abiotic stimulus, response to endogenous stimulus, response to hormone stimulus, response to organic substance, regulation of cell-substrate adhesion, negative regulation of cell-substrate adhesion, cell migration, protein processing, ovulation cycle process, regulation of cell adhesion, respiratory tube development, lung development,zymogen activation, multicellular organism reproduction, tube morphogenesis, tube development, gliogenesis,ovulation cycle, astrocyte cell migration, response to estrogen stimulus, regulation of cellular component biogenesis,development of primary sexual characteristics, development of primary female sexual characteristics, female sex differentiation, rhythmic process, blood vessel morphogenesis, response to steroid hormone stimulus, reproductive structure development, reproductive process in a multicellular organism, branching morphogenesis of a tube, tissue remodeling, cell motility, negative regulation of cellular component organization, protein maturation, protein maturation by peptide bond cleavage, localization of cell, regulation of focal adhesion formation, negative regulation of focal adhesion formation, bone development, respiratory system development, response to oxygen levels,

Membrane ; Single-pass type I membrane protein . Melanosome. Cytoplasm. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm.

Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors.