NOS2, INOS

Nitric oxide synthase, inducible ;
Hepatocyte NOS ;
HEP-NOS ;
Inducible NO synthase ;
Inducible NOS ;
iNOS ;
NOS type II ;
Peptidyl-cysteine S-nitrosylase NOS2 ;

catalytic activity:L-arginine + n NADPH + n H(+) + m O(2) = citrulline + nitric oxide + n NADP(+).,cofactor:Binds 1 FAD.,cofactor:Binds 1 FMN.,cofactor:Heme group.,cofactor:Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme.,enzyme regulation:Regulated by calcium/calmodulin. Aspirin inhibits expression and function of this enzyme and effects may be exerted at the level of translational/post-translational modification and directly on the catalytic activity.,function:Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions.,induction:By endotoxins and cytokines.,online information:Nitric oxide synthase entry,similarity:Belongs to the NOS family.,similarity:Contains 1 FAD-binding FR-type domain.,similarity:Contains 1 flavodoxin-like domain.,subunit:Homodimer. Binds SLC9A3R1.,tissue specificity:Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets.,

blood vessel development, response to hypoxia, regulation of leukocyte mediated cytotoxicity, positive regulation of leukocyte mediated cytotoxicity, endothelial cell proliferation, vasculature development, blood vessel remodeling,innate immune response in mucosa, organ or tissue specific immune response, mucosal immune response, positive regulation of immune system process, regulation of immune effector process, positive regulation of immune effector process, regulation of peptide secretion, circulatory system process, arginine metabolic process, arginine catabolic process, oxygen and reactive oxygen species metabolic process, superoxide metabolic process, nitric oxide biosynthetic process, defense response, immune response, cell surface receptor linked signal transduction, G-protein coupled receptor protein signaling pathway, G-protein signaling, coupled to cyclic nucleotide second messenger, G-protein signaling, coupled to cGMP nucleotide second messenger, intracellular signaling cascade, protein kinase cascade, blood circulation, regulation of heart contraction, regulation of blood pressure, cell proliferation, cellular amino acid catabolic process, glutamine family amino acid metabolic process, glutamine family amino acid catabolic process, amine catabolic process, response to bacterium, organic acid catabolic process, second-messenger-mediated signaling, cGMP-mediated signaling, cyclic-nucleotide-mediated signaling, intracellular receptor-mediated signaling pathway, regulation of cell killing, positive regulation of cell killing, regulation of cell proliferation, defense response to bacterium, regulation of cellular respiration, regulation of generation of precursor metabolites and energy, regulation of multi-organism process, positive regulation of multi-organism process, regulation of system process, nitrogen compound biosynthetic process, innate immune response, nitric oxide metabolic process, carboxylic acid catabolic process, regulation of hormone secretion, retinoic acid receptor signaling pathway, blood vessel morphogenesis,tissue remodeling, regulation of insulin secretion, defense response to Gram-negative bacterium, regulation of secretion, regulation of killing of cells of another organism, positive regulation of killing of cells of another organism,oxidation reduction, regulation of cellular localization, response to oxygen levels,

Cytoplasm, cytosol . Localizes as discrete foci scattered throughout the cytosol and in the presence of SPSB1 and SPSB4, exhibits a more diffuse cytosolic localization. .

Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets. Expressed in chondrocytes (PubMed:7504305).