HDAC10

Histone deacetylase 10 ;
HD10 ;

catalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.,function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.,similarity:Belongs to the histone deacetylase family. Type 2 subfamily.,subcellular location:Excluded from the nucleoli.,subunit:Interacts with HDAC2, HDAC3 and NCOR2.,tissue specificity:Ubiquitous. High expression in liver, spleen, pancreas and kidney.,

negative regulation of transcription from RNA polymerase II promoter, chromatin organization, transcription, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, protein amino acid deacetylation, negative regulation of biosynthetic process, negative regulation of macromolecule biosynthetic process,negative regulation of macromolecule metabolic process, negative regulation of gene expression, negative regulation of transcription, chromatin modification, covalent chromatin modification, histone modification, histone deacetylation,negative regulation of cellular biosynthetic process, regulation of transcription, negative regulation of transcription, DNA-dependent, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process,negative regulation of nitrogen compound metabolic process, regulation of RNA metabolic process, negative regulation of RNA metabolic process, chromosome organization,

Cytoplasm . Nucleus . Excluded from nucleoli. .

Widely expressed with high levels in liver and kidney.