HDAC1

Histone deacetylase 1 ;
HD1 ;

catalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.,function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.,PTM:Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes.,PTM:Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1.,similarity:Belongs to the histone deacetylase family. Type 1 subfamily.,subunit:Part of the core histone deacetylase (HDAC) complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core complex associates with MTA2, MBD2, MBD3, MTA1L1, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylation (NuRD) complex, or with SIN3, SAP18 and SAP30 to form the SIN3 HDAC complex. Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, AOF2/LSD1, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Associates with the 9-1-1 complex; interacts with HUS1. Found in a complex with DNMT3A and HDAC7. Interacts with BCOR, BRMS1L, DAXX, DNMT1, EP300, HCFC1, NFE4, PCAF, PHB2, MIER1, KDM4A, MINT, NRIP1, PRDM6, RERE, SETDB1, SUV39H1, TGIF, TGIF2, UHRF1, UHRF2 and ZNF541. Interacts with the non-histone region of H2AFY. Interacts with HDAC9. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2. Interacts with BANP, CBFA2T3 and KDM5B. Interacts with SAP30L. Interacts with E4F1. Interacts with KFL1 (By similarity). Interacts with SV40 large T antigen.,tissue specificity:Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain.,

negative regulation of transcription from RNA polymerase II promoter, chromatin organization, chromatin remodeling,transcription, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter,protein amino acid deacetylation, anti-apoptosis, positive regulation of cell proliferation, negative regulation of biosynthetic process, positive regulation of biosynthetic process, regulation of specific transcription from RNA polymerase II promoter, positive regulation of specific transcription from RNA polymerase II promoter, negative regulation of specific transcription from RNA polymerase II promoter, positive regulation of macromolecule biosynthetic process, negative regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, negative regulation of macromolecule metabolic process, positive regulation of gene expression, negative regulation of gene expression, regulation of myotube differentiation, negative regulation of myotube differentiation,regulation of receptor biosynthetic process, positive regulation of receptor biosynthetic process, regulation of cell death, regulation of striated muscle tissue development, negative regulation of transcription, chromatin modification,covalent chromatin modification, histone modification, histone deacetylation, negative regulation of cellular biosynthetic process, positive regulation of cellular biosynthetic process, negative regulation of gene-specific transcription, regulation of gene-specific transcription, regulation of cell proliferation, regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death, positive regulation of gene-specific transcription, regulation of transcription, negative regulation of cell differentiation, negative regulation of cell cycle, negative regulation of transcription, DNA-dependent, positive regulation of transcription, DNA-dependent, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, regulation of muscle development,regulation of skeletal muscle tissue development, regulation of skeletal muscle fiber development, regulation of muscle cell differentiation, negative regulation of muscle cell differentiation, regulation of striated muscle cell differentiation, negative regulation of striated muscle cell differentiation, negative regulation of nitrogen compound metabolic process, positive regulation of nitrogen compound metabolic process, regulation of RNA metabolic process,negative regulation of RNA metabolic process, positive regulation of RNA metabolic process, chromosome organization,regulation of cell cycle, regulation of cell development, negative regulation of cell death,

Nucleus .

Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain.