HSP90B1

Endoplasmin ;
94 kDa glucose-regulated protein ;
GRP-94 ;
Heat shock protein 90 kDa beta member 1 ;
Tumor rejection antigen 1 ;
gp96 homolog ;

function:Molecular chaperone that functions in the processing and transport of secreted proteins. Has ATPase activity.,PTM:Phosphorylated.,similarity:Belongs to the heat shock protein 90 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer; disulfide-linked. Component of an EIF2 complex at least composed of CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5 (By similarity). Part a large chaperone multiprotein complex comprising CABP1, DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.,

response to hypoxia, protein folding, proteolysis, ubiquitin-dependent protein catabolic process, cellular ion homeostasis, cellular calcium ion homeostasis, cellular metal ion homeostasis, anti-apoptosis, protein localization,macromolecule catabolic process, proteasomal protein catabolic process, regulation of cell death, protein transport,cellular homeostasis, modification-dependent protein catabolic process, cellular cation homeostasis, cellular di-, tri-valent inorganic cation homeostasis, protein catabolic process, ER-associated protein catabolic process, homeostatic process, regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death, proteasomal ubiquitin-dependent protein catabolic process, modification-dependent macromolecule catabolic process, cellular protein catabolic process, cellular macromolecule catabolic process, establishment of protein localization, chemical homeostasis, ion homeostasis, sequestering of calcium ion,maintenance of location, sequestering of metal ion, proteolysis involved in cellular protein catabolic process, metal ion homeostasis, di-, tri-valent inorganic cation homeostasis, calcium ion homeostasis, cation homeostasis, cellular chemical homeostasis, negative regulation of cell death, response to oxygen levels,

Endoplasmic reticulum lumen . Sarcoplasmic reticulum lumen . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .