GRM4

Metabotropic glutamate receptor 4 ;
mGluR4 ;

function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.,similarity:Belongs to the G-protein coupled receptor 3 family.,subunit:Interacts with PICK1.,tissue specificity:Strongly expressed in the cerebellum. Expressed at low levels in hippocampus, hypothalamus and thalamus. No expression detected in liver.,

MAPKKK cascade, activation of MAPK activity, regulation of neurotransmitter levels, generation of a signal involved in cell-cell signaling, regulation of nucleotide metabolic process, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, neurotransmitter transport, cell surface receptor linked signal transduction, G-protein coupled receptor protein signaling pathway, G-protein signaling, coupled to cyclic nucleotide second messenger, G-protein signaling, coupled to cAMP nucleotide second messenger, inhibition of adenylate cyclase activity by G-protein signaling, negative regulation of adenylate cyclase activity, inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway, glutamate signaling pathway, metabotropic glutamate receptor signaling pathway, intracellular signaling cascade, protein kinase cascade, cell-cell signaling, synaptic transmission, neurotransmitter secretion, behavior, learning or memory, learning, positive regulation of signal transduction, regulation of protein kinase cascade, positive regulation of cell communication, positive regulation of protein kinase cascade, regulation of cell death, phosphorylation, regulation of phosphate metabolic process,transmission of nerve impulse, second-messenger-mediated signaling, cAMP-mediated signaling, cyclic-nucleotide-mediated signaling, regulation of cyclic nucleotide metabolic process, regulation of cyclic nucleotide biosynthetic process, regulation of nucleotide biosynthetic process, regulation of cAMP metabolic process, regulation of cAMP biosynthetic process, regulation of cyclase activity, negative regulation of cyclase activity, secretion by cell, positive regulation of kinase activity, regulation of phosphorylation, regulation of apoptosis, regulation of programmed cell death, positive regulation of catalytic activity, negative regulation of catalytic activity, regulation of MAP kinase activity,positive regulation of MAP kinase activity, regulation of MAPKKK cascade, positive regulation of MAPKKK cascade,regulation of neuron apoptosis, neuroprotection, regulation of kinase activity, negative regulation of molecular function, positive regulation of molecular function, regulation of adenylate cyclase activity, regulation of protein kinase activity, positive regulation of protein kinase activity, secretion, neurological system process, cognition, regulation of phosphorus metabolic process, regulation of transferase activity, regulation of lyase activity, positive regulation of transferase activity, negative regulation of lyase activity,

Cell membrane ; Multi-pass membrane protein .

Strongly expressed in the cerebellum. Expressed at low levels in hippocampus, hypothalamus and thalamus. No expression detected in liver.