DDIT3

DNA damage-inducible transcript 3 protein ;
DDIT-3 ;
C/EBP-homologous protein ;
CHOP ;
C/EBP-homologous protein 10 ;
CHOP-10 ;
Growth arrest and DNA damage-inducible protein GADD153 ;

disease:A chromosomal aberration involving DDIT3 is found in a form of malignant myxoid liposarcoma [MIM:126337]. Translocation t(12;16)(q13;p11) with FUS.,function:Inhibits the DNA-binding activity of C/EBP and LAP by forming heterodimers that cannot bind DNA.,similarity:Belongs to the bZIP family.,similarity:Contains 1 bZIP domain.,subunit:Heterodimer.,

response to reactive oxygen species, response to amphetamine, transcription, transcription, DNA-dependent,regulation of transcription, DNA-dependent, transcription from RNA polymerase II promoter, response to DNA damage stimulus, response to oxidative stress, ER overload response, ER-nuclear signaling pathway, response to unfolded protein, cell cycle, cell cycle arrest, aging, response to nutrient, mRNA transcription, response to endogenous stimulus,positive regulation of biosynthetic process, response to extracellular stimulus, response to organic substance,response to inorganic substance, response to organic nitrogen, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, positive regulation of gene expression, regulation of cell death, positive regulation of cell death, response to amine stimulus, cellular homeostasis, cell cycle process,endoplasmic reticulum unfolded protein response, positive regulation of cellular biosynthetic process, response to nutrient levels, RNA biosynthetic process, negative regulation of CREB transcription factor activity, cellular response to stress, cellular response to unfolded protein, response to endoplasmic reticulum stress, response to drug, response to hydrogen peroxide, homeostatic process, mRNA transcription from RNA polymerase II promoter, regulation of apoptosis, positive regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, negative regulation of DNA binding, negative regulation of transcription factor activity, negative regulation of molecular function, regulation of transcription, cell redox homeostasis, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, embryonic organ development, regulation of transcription factor activity, regulation of binding, negative regulation of binding, regulation of DNA binding, positive regulation of nitrogen compound metabolic process, regulation of RNA metabolic process,response to protein stimulus,

Cytoplasm . Nucleus . Present in the cytoplasm under non-stressed conditions and ER stress leads to its nuclear accumulation. .