FHIT

Bis ;
5'-adenosyl ;
-triphosphatase ;
AP3A hydrolase ;
AP3Aase ;
Diadenosine 5',5'''-P1,P3-triphosphate hydrolase ;
Dinucleosidetriphosphatase ;
Fragile histidine triad protein ;

catalytic activity:P(1)-P(3)-bis(5'-adenosyl) triphosphate + H(2)O = ADP + AMP.,cofactor:Divalent cations. Magnesium, but manganese and to a lesser extent calcium or cobalt can be substituted; but not zinc, cadmium or nickel.,disease:A chromosomal aberration involving FHIT is observed in early onset bilateral and multifocal clear cell renal carcinoma [MIM:144700]. Translocation t(3;8) (3p14.2).,disease:Associated with digestive tract cancers. Numerous tumor types are found to have aberrant forms of FHIT protein due to deletions in a coding region of chromosome 3p14.2 including the fragile site locus FRA3B.,function:Cleaves A-5'-PPP-5'A to yield AMP and ADP. Possible tumor suppressor for specific tissues.,mass spectrometry: PubMed:15007172,similarity:Contains 1 HIT domain.,subunit:Homodimer.,tissue specificity:Low levels expressed in all tissues tested. Phospho-FHIT observed in liver and kidney, but not in brain and lung. Phospho-FHIT undetected in all tested human tumor cell lines.,

purine nucleoside catabolic process, DNA metabolic process, DNA replication, nucleoside metabolic process,ribonucleoside metabolic process, nucleoside catabolic process, bis(5'-nucleosidyl) oligophosphate metabolic process,bis(5'-nucleosidyl) oligophosphate catabolic process, diadenosine polyphosphate metabolic process, diadenosine polyphosphate catabolic process, diadenosine triphosphate metabolic process, diadenosine triphosphate catabolic process, nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, nucleobase, nucleoside and nucleotide catabolic process, purine nucleoside metabolic process, ribonucleoside catabolic process, nitrogen compound catabolic process, purine ribonucleoside metabolic process, purine ribonucleoside catabolic process, heterocycle catabolic process,

Cytoplasm . Mitochondrion . Nucleus .

Low levels expressed in all tissues tested. Phospho-FHIT observed in liver and kidney, but not in brain and lung. Phospho-FHIT undetected in all tested human tumor cell lines.