Total DNA pol β Cell-Based Colorimetric ELISA Kit
-KA3243C
主要信息
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
Unmodified
详细信息
储存
2-8°C/6 months
修饰
Unmodified
检测方法
Colorimetric
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抗原&靶点信息
基因名称:
POLB
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别名:
DNA polymerase beta ;
EC 4.2.99.- ;
EC 4.2.99.- ;
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背景:
catalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).,cofactor:Binds 2 magnesium ions per subunit.,domain:Residues 239-252 form a flexible loop which appears to affect the polymerase fidelity.,function:Repair polymerase. Conducts "gap-filling" DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.,PTM:Methylation by PRMT6 stimulates the polymerase activity by enhancing DNA binding and processivity.,similarity:Belongs to the DNA polymerase type-X family.,subunit:Monomer.,
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功能:
DNA metabolic process, DNA replication, DNA-dependent DNA replication, DNA repair, base-excision repair, pyrimidine dimer repair, anti-apoptosis, response to DNA damage stimulus, cell death, regulation of cell death, death, cellular response to stress, regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death,negative regulation of programmed cell death, negative regulation of cell death,
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细胞定位:
Nucleus. Cytoplasm. Cytoplasmic in normal conditions. Translocates to the nucleus following DNA damage.
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