CCNA1/CCNA2

developmental stage:Expression increases in early G1 phase and reaches highest levels during the S and G2/M phases.,function:May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.,similarity:Belongs to the cyclin family.,similarity:Belongs to the cyclin family. Cyclin AB subfamily.,subunit:Interacts with the CDK2 and the CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Does not bind CDK4 and CDK5 (in vitro). The cyclin A1-CDK2 complex interacts with transcription factor E2F-1 and RB proteins. Found in a complex with CDK2, CABLES1 and CCNE1 (By similarity). Interacts with INCA1 and KLHDC9.,tissue specificity:Very high levels in testis and very low levels in brain. Also found in myeloid Leukemia cell lines.,

M phase of mitotic cell cycle, mitotic cell cycle, M phase, nuclear division, cell cycle, mitosis, meiosis, male meiosis, male meiosis I, gamete generation, spermatogenesis, sexual reproduction, cell cycle process, cell cycle phase, multicellular organism reproduction, male gamete generation, organelle fission, reproductive process in a multicellular organism,cell division, meiotic cell cycle, M phase of meiotic cell cycle,

Nucleus .

Very high levels in testis and very low levels in brain. Also found in myeloid leukemia cell lines.