PTGS2

Prostaglandin G/H synthase 2 ;
Cyclooxygenase-2 ;
COX-2 ;
PHS II ;
Prostaglandin H2 synthase 2 ;
PGH synthase 2 ;
PGHS-2 ;
Prostaglandin-endoperoxide synthase 2 ;

catalytic activity:Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O.,cofactor:Binds 1 heme B (iron-protoporphyrin IX) group per subunit.,disease:Likely to play a role in inflammatory diseases such as rheumatoid arthritis.,function:May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.,induction:By cytokines and mitogens.,miscellaneous:This enzyme acts both as a dioxygenase and as a peroxidase.,miscellaneous:This enzyme is the target of nonsteroidal anti-inflammatory drugs such as aspirin.,pathway:Lipid metabolism; prostaglandin biosynthesis.,similarity:Belongs to the prostaglandin G/H synthase family.,similarity:Contains 1 EGF-like domain.,subunit:Homodimer.,

very-long-chain fatty acid metabolic process, skeletal system development, ossification, prostaglandin biosynthetic process, placenta development, maternal placenta development, hair follicle development, response to molecule of bacterial origin, reproductive developmental process, circulatory system process, fatty acid metabolic process, fatty acid biosynthetic process, unsaturated fatty acid biosynthetic process, icosanoid metabolic process, prostanoid metabolic process, prostaglandin metabolic process, cell motion, regulation of muscle contraction, regulation of smooth muscle contraction, response to oxidative stress, gamete generation, female gamete generation, ectoderm development, female pregnancy, embryo implantation, response to nutrient, behavior, learning or memory, memory,blood circulation, regulation of blood pressure, positive regulation of cell proliferation, negative regulation of cell proliferation, epidermis development, lipid biosynthetic process, response to bacterium, response to endogenous stimulus, response to hormone stimulus, response to carbohydrate stimulus, response to hexose stimulus, response to fructose stimulus, response to extracellular stimulus, response to organic substance, response to inorganic substance, response to metal ion, response to manganese ion, response to organic nitrogen, positive regulation of cell communication, negative regulation of cell communication, regulation of cell death, positive regulation of cell death,regulation of metal ion transport, response to organic cyclic substance, organic acid biosynthetic process, regulation of vasoconstriction, arachidonic acid metabolic process, sexual reproduction, developmental maturation, molting cycle process, hair cycle process, bone mineralization, ovulation, biomineral formation, regulation of neurological system process, negative regulation of neurological system process, positive regulation of neurological system process,response to nutrient levels, positive regulation of synaptic plasticity, response to corticosteroid stimulus, regulation of response to external stimulus, regulation of synaptic transmission, dopaminergic, negative regulation of synaptic transmission, dopaminergic, response to estradiol stimulus, response to lipopolysaccharide, multicellular organism reproduction, response to vitamin, response to vitamin D, unsaturated fatty acid metabolic process, response to cytokine stimulus, response to monosaccharide stimulus, growth, regulation of cell proliferation, molting cycle,response to drug, hair cycle, anagen, regulation of apoptosis, positive regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, regulation of ion transport, negative regulation of ion transport, response to estrogen stimulus, regulation of system process, positive regulation of vasoconstriction,positive regulation of muscle contraction, positive regulation of smooth muscle contraction, carboxylic acid biosynthetic process, icosanoid biosynthetic process, prostanoid biosynthetic process, decidualization, regulation of synaptic plasticity, response to steroid hormone stimulus, developmental growth, reproductive process in a multicellular organism, regulation of smooth muscle cell proliferation, positive regulation of smooth muscle cell proliferation, hair follicle maturation, regulation of inflammatory response, regulation of synaptic transmission, negative regulation of synaptic transmission, positive regulation of synaptic transmission, neurological system process, cognition, negative regulation of transport, positive regulation of multicellular organismal process, negative regulation of multicellular organismal process, response to glucocorticoid stimulus, regulation of cell cycle, regulation of calcium ion transport,negative regulation of calcium ion transport, regulation of synaptic transmission, glutamatergic, positive regulation of synaptic transmission, glutamatergic, regulation of transmission of nerve impulse, negative regulation of transmission of nerve impulse, positive regulation of transmission of nerve impulse, oxidation reduction, bone development,

Microsome membrane ; Peripheral membrane protein. Endoplasmic reticulum membrane ; Peripheral membrane protein. Nucleus inner membrane ; Peripheral membrane protein. Nucleus outer membrane ; Peripheral membrane protein. Detected on the lumenal side of the endoplasmic reticulum and nuclear envelope. .