PTGS1

Prostaglandin G/H synthase 1 ;
Cyclooxygenase-1 ;
COX-1 ;
Prostaglandin H2 synthase 1 ;
PGH synthase 1 ;
PGHS-1 ;
PHS 1 ;
Prostaglandin-endoperoxide synthase 1 ;

catalytic activity:Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O.,cofactor:Binds 1 heme B (iron-protoporphyrin IX) group per subunit.,function:May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.,miscellaneous:This enzyme acts both as a dioxygenase and as a peroxidase.,miscellaneous:This enzyme is the target of nonsteroidal anti-inflammatory drugs such as aspirin.,pathway:Lipid metabolism; prostaglandin biosynthesis.,similarity:Belongs to the prostaglandin G/H synthase family.,similarity:Contains 1 EGF-like domain.,subunit:Homodimer.,

prostaglandin biosynthetic process, circulatory system process, fatty acid metabolic process, fatty acid biosynthetic process, unsaturated fatty acid biosynthetic process, icosanoid metabolic process, prostanoid metabolic process,prostaglandin metabolic process, regulation of muscle contraction, regulation of smooth muscle contraction, response to oxidative stress, aging, blood circulation, regulation of blood pressure, lipid biosynthetic process, response to endogenous stimulus, response to hormone stimulus, response to organic substance, response to organic nitrogen,negative regulation of norepinephrine secretion, regulation of epinephrine secretion, regulation of norepinephrine secretion, organic acid biosynthetic process, regulation of vasoconstriction, response to corticosteroid stimulus,negative regulation of epinephrine secretion, unsaturated fatty acid metabolic process, negative regulation of catecholamine secretion, regulation of cell proliferation, regulation of system process, positive regulation of vasoconstriction, positive regulation of muscle contraction, positive regulation of smooth muscle contraction, carboxylic acid biosynthetic process, icosanoid biosynthetic process, prostanoid biosynthetic process, response to steroid hormone stimulus, regulation of catecholamine secretion, regulation of secretion, negative regulation of secretion,negative regulation of transport, positive regulation of multicellular organismal process, response to glucocorticoid stimulus, response to mineralocorticoid stimulus, response to corticosterone stimulus, regulation of amine transport,negative regulation of amine transport, oxidation reduction, regulation of cellular localization,

Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.