CSE1L

Exportin-2 ;
Exp2 ;
Cellular apoptosis susceptibility protein ;
Chromosome segregation 1-like protein ;
Importin-alpha re-exporter ;

function:Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.,similarity:Belongs to the XPO2/CSE1 family.,similarity:Contains 1 importin N-terminal domain.,subcellular location:Shuttles between the nucleus and the cytoplasm.,subunit:Found in a complex with CSE1L/XPO2, Ran and KPNA2. Binds with high affinity to importin-alpha only in the presence of RanGTP. The complex is dissociated by the combined action of RanBP1 and RanGAP1.,tissue specificity:Highly expressed in proliferating cells.,

protein import into nucleus, docking, protein complex assembly, protein targeting, protein import into nucleus,intracellular protein transport, nucleocytoplasmic transport, apoptosis, protein localization, cell death, cell proliferation,programmed cell death, protein transport, death, protein import, protein localization in organelle, protein localization in nucleus, cellular protein localization, cellular macromolecular complex subunit organization, cellular macromolecular complex assembly, cellular protein complex assembly, macromolecular complex subunit organization, establishment of protein localization, intracellular transport, nuclear transport, nuclear import, macromolecular complex assembly,protein complex biogenesis, cellular macromolecule localization,

Cytoplasm . Nucleus . Shuttles between the nucleus and the cytoplasm. .

Detected in brain, placenta, ovary, testis and trachea (at protein level) (PubMed:10331944). Widely expressed (PubMed:10331944). Highly expressed in testis and in proliferating cells (PubMed:7479798,PubMed:10331944).