CASP6

Caspase-6 ;
CASP-6 ;
Apoptotic protease Mch-2 ;
[Cleaved into: Caspase-6 subunit p18 ;
Caspase-6 subunit p11]

catalytic activity:Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp-|-.,enzyme regulation:Activation is suppressed by phosphorylation at Ser-257.,function:Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.,PTM:Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits.,similarity:Belongs to the peptidase C14A family.,subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit.,

response to reactive oxygen species, eye development, lens development in camera-type eye, acute inflammatory response to non-antigenic stimulus, acute inflammatory response, proteolysis, apoptosis, induction of apoptosis,defense response, inflammatory response, response to oxidative stress, sensory organ development, cell death,response to temperature stimulus, response to radiation, response to heat, response to wounding, response to abiotic stimulus, response to endogenous stimulus, response to hormone stimulus, response to carbohydrate stimulus, response to hexose stimulus, response to glucose stimulus, response to organic substance, response to inorganic substance, response to metal ion, response to iron ion, response to ionizing radiation, response to organic nitrogen, response to gamma radiation, regulation of cell death, positive regulation of cell death, programmed cell death, induction of programmed cell death, death, response to estradiol stimulus, response to testosterone stimulus,response to cytokine stimulus, response to monosaccharide stimulus, response to hydrogen peroxide, regulation of apoptosis, camera-type eye development, positive regulation of apoptosis, regulation of programmed cell death,positive regulation of programmed cell death, regulation of neuron apoptosis, positive regulation of neuron apoptosis,response to estrogen stimulus, regulation of retinal cell programmed cell death, positive regulation of retinal cell programmed cell death, response to steroid hormone stimulus, positive regulation of developmental process,regulation of cell development,

Cytoplasm . Nucleus .