SP1

Transcription factor Sp1

function:Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites. Can interact with G/C-rich motifs from serotonin receptor promoter.,PTM:O-glycosylated; contains N-acetylglucosamine side chains.,similarity:Belongs to the Sp1 C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,subunit:Interacts with ATF7IP, ATF7IP2, POGZ, HCFC1, AATF and PHC2. Interacts with varicella-zoster virus IE62 protein and HIV-1 Vpr. Interacts with SV40 VP2/3 proteins. Interacts with SV40 major capsid protein VP1; this interaction leads to a cooperativity between the two proteins in DNA binding.,

skeletal system development, ossification, eye development, in utero embryonic development, blastocyst development, blastocyst formation, trophectodermal cell differentiation, liver development, placenta development,embryonic placenta development, immune system development, transcription, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, regulation of transcription from RNA polymerase II promoter, global, sensory organ development, female pregnancy, embryonic development ending in birth or egg hatching, positive regulation of biosynthetic process, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, positive regulation of gene expression, hemopoiesis,myeloid cell differentiation, erythrocyte differentiation, megakaryocyte differentiation, respiratory tube development,lung development, embryonic camera-type eye development, positive regulation of cellular biosynthetic process,multicellular organism reproduction, erythrocyte homeostasis, tube development, homeostatic process, chordate embryonic development, camera-type eye development, enucleate erythrocyte differentiation, regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, global, positive regulation of transcription, DNA-dependent, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter,embryonic eye morphogenesis, hemopoietic or lymphoid organ development, embryonic organ morphogenesis,embryonic organ development, eye morphogenesis, camera-type eye morphogenesis, embryonic camera-type eye morphogenesis, embryonic morphogenesis, reproductive process in a multicellular organism, embryonic skeletal system development, homeostasis of number of cells, positive regulation of nitrogen compound metabolic process,regulation of RNA metabolic process, positive regulation of RNA metabolic process, embryonic process involved in female pregnancy, definitive hemopoiesis, bone development, respiratory system development,

Nucleus. Cytoplasm. Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location.

Up-regulated in adenocarcinomas of the stomach (at protein level). Isoform 3 is ubiquitously expressed at low levels.