BCL2L11

Bcl-2-like protein 11 ;
Bcl2-L-11 ;
Bcl2-interacting mediator of cell death ;

domain:The BH3 motif is required for Bcl-2 binding and cytotoxicity.,function:Induces apoptosis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than the isoforms BimEL, BimL and BimS. Isoform Bim-gamma induces apoptosis.,similarity:Belongs to the Bcl-2 family.,subcellular location:Associated with intracytoplasmic membranes.,subunit:Forms heterodimers with a number of antiapoptotic Bcl-2 proteins including MCL1, BCL2, BCL2L1 isoform Bcl-X(L), BCL2A1/BFL-1, and BHRF1. Does not heterodimerize with proapoptotic proteins such as BAD, BOK, BAX or BAK.,tissue specificity:Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are ubiquitously expressed with a tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney.,

urogenital system development, in utero embryonic development, leukocyte homeostasis, B cell homeostasis, B cell apoptosis, kidney development, lymphocyte homeostasis, myeloid cell homeostasis, immune system development,reproductive developmental process, apoptosis, induction of apoptosis, cell adhesion, cell-matrix adhesion, gamete generation, spermatogenesis, sensory organ development, sex differentiation, cell death, gonad development, male gonad development, induction of apoptosis by extracellular signals, activation of pro-apoptotic gene products, post-embryonic development, embryonic development ending in birth or egg hatching, post-embryonic morphogenesis,regulation of cell death, positive regulation of cell death, programmed cell death, induction of programmed cell death,death, sexual reproduction, biological adhesion, mammary gland development, cell-substrate adhesion, multicellular organism reproduction, tube lumen formation, tube morphogenesis, tube development, regulation of growth,odontogenesis of dentine-containing tooth, odontogenesis, homeostatic process, regulation of apoptosis, chordate embryonic development, T cell homeostasis, positive regulation of apoptosis, regulation of programmed cell death,positive regulation of programmed cell death, ear development, development of primary sexual characteristics,development of primary male sexual characteristics, regulation of organ growth, male sex differentiation, regulation of pigmentation during development, male gamete generation, hemopoietic or lymphoid organ development, spleen development, thymus development, post-embryonic organ morphogenesis, post-embryonic organ development,reproductive structure development, reproductive process in a multicellular organism, gland development,homeostasis of number of cells, lymphocyte apoptosis,

Endomembrane system ; Peripheral membrane protein . Associated with intracytoplasmic membranes. .; [Isoform BimEL]: Mitochondrion. Translocates from microtubules to mitochondria on loss of cell adherence.; [Isoform BimL]: Mitochondrion.; [Isoform BimS]: Mitochondrion.; [Isoform Bim-alpha1]: Mitochondrion.

Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are widely expressed with tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney.