ATF4

Cyclic AMP-dependent transcription factor ATF-4 ;
cAMP-dependent transcription factor ATF-4 ;
Activating transcription factor 4 ;
Cyclic AMP-responsive element-binding protein 2 ;
CREB-2 ;
cAMP-responsive element-binding protein 2 ;
DNA-binding protein TAXREB67 ;
Tax-responsive enhancer element-binding protein 67 ;
TaxREB67 ;

function:Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I.,similarity:Belongs to the bZIP family.,similarity:Contains 1 bZIP domain.,subcellular location:Colocalizes with GABBR1 in hippocampal neuron dendritic membranes.,subunit:Interacts with the C-terminal region of GABBR1 via the leucine zipper of its C-terminal bZIP domain. Interacts with the C-terminal region of GABBR2 (By similarity). Binds DNA as a homo-or heterodimer. Interacts with the N-terminal region of CEP290.,

monosaccharide metabolic process, glucose metabolic process, pyruvate metabolic process, gluconeogenesis,transcription, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter,positive regulation of biosynthetic process, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, positive regulation of gene expression, carbohydrate biosynthetic process, hexose metabolic process, hexose biosynthetic process, positive regulation of cellular biosynthetic process,cellular response to stress, cellular carbohydrate biosynthetic process, response to endoplasmic reticulum stress,regulation of transcription, positive regulation of transcription, DNA-dependent, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, alcohol biosynthetic process, monosaccharide biosynthetic process,positive regulation of nitrogen compound metabolic process, regulation of RNA metabolic process, positive regulation of RNA metabolic process,

Nucleus . Nucleus speckle . Cytoplasm . Cell membrane . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity). Colocalizes with NEK6 at the centrosome (PubMed:20873783). Recruited to nuclear speckles following interaction with EP300/p300 (PubMed:16219772). .