AKT1S1

Proline-rich AKT1 substrate 1 ;
40 kDa proline-rich AKT substrate ;

function:May play an important role in phosphatidylinositol 3-kinase (PI3K)-AKT1 survival signaling. Substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. Its role in survival signaling pathways may be modulated by oxidative stress. May also play a role in nerve growth factor-mediated neuroprotection.,subcellular location:Found in the cytosolic fraction of the brain.,subunit:The phosphorylated form interacts with 14-3-3.,tissue specificity:Widely expressed with highest levels of expression in liver and heart. Expressed at higher levels in cancer cell lines (e.g. A549 and HeLa) than in normal cell lines (e.g. HEK293).,

negative regulation of protein kinase activity, anti-apoptosis, regulation of cell size, negative regulation of signal transduction, negative regulation of cell communication, regulation of cell death, regulation of phosphate metabolic process, regulation of TOR signaling pathway, negative regulation of TOR signaling pathway, regulation of cellular component size, negative regulation of kinase activity, regulation of phosphorylation, regulation of apoptosis,negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death,negative regulation of catalytic activity, regulation of neuron apoptosis, neuroprotection, regulation of kinase activity,negative regulation of molecular function, negative regulation of cell size, regulation of protein kinase activity,regulation of survival gene product expression, regulation of phosphorus metabolic process, regulation of transferase activity, negative regulation of transferase activity, negative regulation of cell death,

Cytoplasm, cytosol . Found in the cytosolic fraction of the brain. .

Widely expressed with highest levels of expression in liver and heart. Expressed at higher levels in cancer cell lines (e.g. A-549 and HeLa) than in normal cell lines (e.g. HEK293).