ABL1

Abelson tyrosine-protein kinase 2 ;
Abelson murine leukemia viral oncogene homolog 2 ;
Abelson-related gene protein ;
Tyrosine-protein kinase ARG ;

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,cofactor:Magnesium or manganese.,enzyme regulation:Stabilized in the inactive form by an association between the SH3 domain and the SH2-TK linker region, interactions of the amino-terminal cap, and contributions from an amino-terminal myristoyl group and phospholipids. Activated by autophosphorylation as well as by SRC-family kinase-mediated phosphorylation. Activated by RIN1 binding to the SH2 and SH3 domains. Inhibited by imatinib mesylate (Gleevec) which is used for the treatment of chronic myeloid leukemia (CML).,function:Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,tissue specificity:Widely expressed.,

protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, cytoskeleton organization, actin filament organization, cell adhesion, phosphorylation, peptidyl-tyrosine phosphorylation, peptidyl-tyrosine modification, biological adhesion, actin filament-based process, actin cytoskeleton organization, positive regulation of catalytic activity, positive regulation of molecular function, actin filament bundle formation, regulation of oxidoreductase activity, positive regulation of oxidoreductase activity,

Cytoplasm, cytoskeleton.

Widely expressed.