FRS2

Fibroblast growth factor receptor substrate 2 ;
FGFR substrate 2 ;
FGFR-signaling adaptor SNT ;
Suc1-associated neurotrophic factor target 1 ;
SNT-1 ;

function:Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.,PTM:Phosphorylated on tyrosine residues upon stimulation by NGF.,PTM:Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination.,sequence caution:Translated as stop.,similarity:Contains 1 IRS-type PTB domain.,subcellular location:Cytoplasmic, membrane-bound.,subunit:Part of a complex containing FRS2, GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity). Binds FGFR1, SUC1, NTRK1, NTRK2, NTRK3 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11.,tissue specificity:Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.,

MAPKKK cascade, activation of MAPK activity, embryonic axis specification, eye development, gastrulation with mouth forming second, cell fate specification, optic placode formation, induction of an organ, regionalization, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway, transmembrane receptor protein tyrosine phosphatase signaling pathway, G-protein coupled receptor protein signaling pathway, intracellular signaling cascade, protein kinase cascade, cell-cell signaling,blastoderm segmentation, tripartite regional subdivision, gastrulation, pattern specification process, neuroblast proliferation, sensory organ development, cell proliferation, fibroblast growth factor receptor signaling pathway,determination of anterior/posterior axis, embryo, axis specification, embryonic pattern specification, anterior/posterior axis specification, anterior/posterior pattern formation, phosphorylation, regulation of phosphate metabolic process,forebrain development, embryonic camera-type eye development, developmental induction, positive regulation of kinase activity, segmentation, regulation of phosphorylation, camera-type eye development, positive regulation of catalytic activity, regulation of MAP kinase activity, positive regulation of MAP kinase activity, regulation of kinase activity, positive regulation of molecular function, cell fate commitment, cell-cell signaling involved in cell fate specification, regulation of protein kinase activity, positive regulation of protein kinase activity, optic placode formation involved in camera-type eye, embryonic eye morphogenesis, embryonic organ morphogenesis, embryonic organ development, eye morphogenesis, camera-type eye morphogenesis, embryonic camera-type eye morphogenesis,embryonic morphogenesis, regulation of phosphorus metabolic process, regulation of transferase activity, positive regulation of transferase activity,

Endomembrane system. Cytoplasmic, membrane-bound.

Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.