ERBB2

Receptor tyrosine-protein kinase erbB-2 ;
Metastatic lymph node gene 19 protein ;
MLN 19 ;
Proto-oncogene Neu ;
Proto-oncogene c-ErbB-2 ;
Tyrosine kinase-type cell surface receptor HER2 ;
p185erbB2 ;
CD antigen CD340 ;

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Defects in ERBB2 are associated with familial glioma of brain [MIM:137800]; also called glioblastoma multiforme. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas.,disease:Defects in ERBB2 are associated with gastric cancer [MIM:137215]; also known as hereditary familial diffuse gastric cancer (HDGC).,disease:Defects in ERBB2 are associated with lung cancer [MIM:211980]; also called adenocarcinoma of lung.,disease:Defects in ERBB2 are associated with ovarian cancer [MIM:167000]. Ovarian cancer is the leading cause of death from gynecologic malignancy. It is characterized by advanced presentation with loco-regional dissemination in the peritoneal cavity and the rare incidence of visceral metastases. These typical features relate to the biology of the disease, which is a principal determinant of outcome.,function:Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-alpha and amphiregulin.,online information:ERBB2 entry,polymorphism:There are fours alleles due to the variations in positions 654 and 655. Allele B1 (Ile-654/Ile-655) has a frequency of 0.782; allele B2 (Ile-654/Val-655) has a frequency of 0.206; allele B3 (Val-654/Val-655) has a frequency of 0.012.,PTM:Ligand-binding increases phosphorylation on tyrosine residues.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Heterodimer with each of the other ERBB receptors (Potential). Interacts with PRKCABP and PLXNB1. Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts with MEMO when phosphorylated on Tyr-1248. Interacts with MUC1. Stimulation by heregulin (HRG) in breast cancer cell lines induces binding of MUC1 with gamma-catenin.,

cell morphogenesis, cell morphogenesis involved in differentiation, regulation of action potential, liver development,negative regulation of immune system process, regulation of leukocyte activation, negative regulation of leukocyte activation, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, cellular ion homeostasis, cell motion, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway, intracellular signaling cascade, protein kinase cascade, ensheathment of neurons, axonogenesis, axon guidance, peripheral nervous system development,sensory organ development, heart development, muscle organ development, skeletal muscle tissue development,neuromuscular junction development, motor axon guidance, cell proliferation, positive regulation of cell proliferation,negative regulation of cell proliferation, axon ensheathment, response to wounding, response to endogenous stimulus, response to hormone stimulus, positive regulation of signal transduction, glial cell differentiation, response to organic substance, regulation of protein kinase cascade, positive regulation of cell communication, positive regulation of protein kinase cascade, regulation of cell death, phosphoinositide 3-kinase cascade, regulation of phosphoinositide 3-kinase cascade, positive regulation of phosphoinositide 3-kinase cascade, striated muscle tissue development, phosphorylation, peptidyl-tyrosine phosphorylation, peptidyl-tyrosine modification, regulation of phosphate metabolic process, transmission of nerve impulse, regulation of action potential in neuron, cellular homeostasis, second-messenger-mediated signaling, ovulation cycle process, gland morphogenesis, cell projection organization, regulation of cell adhesion, neuron differentiation, mammary gland development, neuron projection development, multicellular organism reproduction, response to progesterone stimulus, regulation of mononuclear cell proliferation, negative regulation of mononuclear cell proliferation, cellular component morphogenesis, cell part morphogenesis, regulation of T cell differentiation in the thymus, regulation of immature T cell proliferation, regulation of immature T cell proliferation in the thymus, negative regulation of immature T cell proliferation, negative regulation of immature T cell proliferation in the thymus, positive regulation of kinase activity, wound healing, gliogenesis,regulation of cell proliferation, regulation of T cell proliferation, negative regulation of T cell proliferation, regulation of phosphorylation, regulation of membrane potential, response to drug, myelination, homeostatic process, muscle cell differentiation, ovulation cycle, regulation of apoptosis, extracellular structure organization, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death, positive regulation of catalytic activity, regulation of MAP kinase activity, positive regulation of MAP kinase activity, regulation of MAPKKK cascade, positive regulation of MAPKKK cascade, regulation of kinase activity, tongue development, positive regulation of molecular function, regulation of T cell differentiation, regulation of lymphocyte differentiation, regulation of angiogenesis, positive regulation of cell adhesion, regulation of protein kinase activity, positive regulation of protein kinase activity, regulation of Ras protein signal transduction, positive regulation of Ras protein signal transduction,protein amino acid autophosphorylation, phosphoinositide-mediated signaling, autonomic nervous system development, sympathetic nervous system development, rhythmic process, response to steroid hormone stimulus,reproductive process in a multicellular organism, neuron development, cell morphogenesis involved in neuron differentiation, response to axon injury, gland development, skeletal muscle fiber development, muscle fiber development, tissue remodeling, neuron projection morphogenesis, cell projection morphogenesis, chemical homeostasis, regulation of lymphocyte proliferation, negative regulation of lymphocyte proliferation, regulation of epithelial cell proliferation, positive regulation of epithelial cell proliferation, ion homeostasis, synapse organization,regulation of T cell activation, regulation of cell activation, negative regulation of cell activation, negative regulation of T cell activation, neurological system process, regulation of small GTPase mediated signal transduction, positive regulation of small GTPase mediated signal transduction, striated muscle cell differentiation, regulation of phosphorus metabolic process, regulation of lymphocyte activation, negative regulation of lymphocyte activation, regulation of transferase activity, positive regulation of transferase activity, muscle cell development, striated muscle cell development, cellular chemical homeostasis, mammary gland involution, estrous cycle phase, estrus, mammary gland morphogenesis, muscle tissue development, skeletal muscle organ development, negative regulation of cell death,regulation of leukocyte proliferation, negative regulation of leukocyte proliferation,

[Isoform 1]: Cell membrane ; Single-pass type I membrane protein. Early endosome . Cytoplasm, perinuclear region. Nucleus. Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1. Also detected in VPS35-positive endosome-to-TGN retrograde vesicles (PubMed:31138794). .; [Isoform 2]: Cytoplasm. Nucleus.; [Isoform 3]: Cytoplasm. Nucleus.

Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.