CREB1

Cyclic AMP-responsive element-binding protein 1 ;
CREB-1 ;
cAMP-responsive element-binding protein 1 ;

disease:A chromosomal aberration involving CREB1 is associated with angiomatoid fibrous histiocytoma (AFH) [MIM:612160]. Translocation t(2;22)(q33;q12) with CREB1 generates a EWSR1/CREB1 fusion gene that is most common genetic abnormality in this tumor type.,function:This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. Transciption activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Implicated in synchronization of circadian rhythmicity.,PTM:Stimulated by phosphorylation. Phosphorylation of both Ser-133 and Ser-142 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-133 allows CREBBP binding (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the bZIP family.,similarity:Contains 1 bZIP domain.,similarity:Contains 1 KID (kinase-inducible) domain.,subunit:Interacts with PPRC1. Binds DNA as a dimer. This dimer is stabilized by magnesium ions. Interacts, through the bZIP domain, with the coactivators TORC1/CRTC1, TORC2/CRTC2 and TORC3/CRTC3. When phosphorylated on Ser-133, binds CREBBP.,

cell morphogenesis, cell morphogenesis involved in differentiation, regulation of cytokine production, positive regulation of cytokine production, transcription, transcription, DNA-dependent, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, protein amino acid phosphorylation,phosphorus metabolic process, phosphate metabolic process, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein serine/threonine kinase signaling pathway, transforming growth factor beta receptor signaling pathway, axonogenesis, lactation, regulation of cell size,positive regulation of biosynthetic process, response to organic substance, regulation of specific transcription from RNA polymerase II promoter, positive regulation of specific transcription from RNA polymerase II promoter, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, positive regulation of gene expression, regulation of cell death, phosphorylation, diencephalon development, pituitary gland development, cell projection organization, neuron differentiation, mammary gland development, forebrain development, neuron projection development, positive regulation of cellular biosynthetic process, multicellular organism reproduction, regulation of cellular component size, regulation of gene-specific transcription, RNA biosynthetic process, regulation of transforming growth factor-beta3 production, positive regulation of transforming growth factor-beta3 production, cellular component morphogenesis, cell part morphogenesis, endocrine system development, regulation of growth, regulation of multicellular organism growth, positive regulation of multicellular organism growth, response to drug, regulation of circadian rhythm, regulation of apoptosis, regulation of programmed cell death, positive regulation of gene-specific transcription, regulation of transcription, positive regulation of transcription, DNA-dependent, positive regulation of growth, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, regulation of hormone secretion, positive regulation of hormone secretion, reproductive process in a multicellular organism, neuron development, cell morphogenesis involved in neuron differentiation, gland development, neuron projection morphogenesis, cell projection morphogenesis, regulation of secretion, positive regulation of secretion, positive regulation of transport, positive regulation of nitrogen compound metabolic process,positive regulation of multicellular organismal process, regulation of RNA metabolic process, positive regulation of RNA metabolic process, regulation of cellular localization,

Nucleus .