IRAK1

Interleukin-1 receptor-associated kinase 1 ;
IRAK-1 ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,function:Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Isoform 1 binds rapidly but is then degraded allowing isoform 2 to mediate a slower, more sustained response to the cytokine. Isoform 2 is inactive suggesting that the kinase activity of this enzyme is not required for IL-1 signaling. Once phosphorylated, IRAK1 recruits the adapter protein PELI1.,PTM:Autophosphorylated or is transphosphorylated by IRAK4 following recruitment to the IL-1RI. In the case of isoform 1, this is linked to ubiquitination and degradation.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.,similarity:Contains 1 protein kinase domain.,subunit:IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. Interacts with IL1RL1. Interacts with IRAK1BP1.,tissue specificity:Isoform 1 and isoform 2 are ubiquitously expressed in all tissues examined, with isoform 1 being more strongly expressed than isoform 2.,

regulation of cytokine-mediated signaling pathway, activation of innate immune response, pattern recognition receptor signaling pathway, toll-like receptor signaling pathway, response to molecule of bacterial origin, activation of immune response, positive regulation of immune system process, MyD88-dependent toll-like receptor signaling pathway, immune response-activating signal transduction, innate immune response-activating signal transduction,immune response-regulating signal transduction, protein complex assembly, protein amino acid phosphorylation,phosphorus metabolic process, phosphate metabolic process, anti-apoptosis, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein serine/threonine kinase signaling pathway, intracellular signaling cascade, protein kinase cascade, I-kappaB kinase/NF-kappaB cascade, activation of NF-kappaB-inducing kinase activity, response to bacterium, positive regulation of biosynthetic process, response to organic substance, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, positive regulation of gene expression, regulation of cell death, phosphorylation,regulation of phosphate metabolic process, cytokine-mediated signaling pathway, positive regulation of cellular biosynthetic process, positive regulation of defense response, lipopolysaccharide-mediated signaling pathway,negative regulation of NF-kappaB transcription factor activity, activation of protein kinase activity, response to lipopolysaccharide, positive regulation of kinase activity, response to cytokine stimulus, toll-like receptor 2 signaling pathway, regulation of phosphorylation, regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death, positive regulation of catalytic activity, positive regulation of DNA binding, negative regulation of DNA binding, negative regulation of transcription factor activity,regulation of kinase activity, macromolecular complex subunit organization, negative regulation of molecular function,positive regulation of molecular function, regulation of innate immune response, positive regulation of innate immune response, regulation of transcription, regulation of protein kinase activity, positive regulation of protein kinase activity,positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, protein amino acid autophosphorylation, positive regulation of response to stimulus, positive regulation of immune response, regulation of transcription factor activity, positive regulation of transcription factor activity,positive regulation of NF-kappaB transcription factor activity, regulation of binding, positive regulation of binding,negative regulation of binding, regulation of DNA binding, positive regulation of nitrogen compound metabolic process,regulation of phosphorus metabolic process, protein oligomerization, regulation of transferase activity, positive regulation of transferase activity, negative regulation of cell death, macromolecular complex assembly, protein complex biogenesis, interleukin-1-mediated signaling pathway, response to interleukin-1,

Cytoplasm . Nucleus . Lipid droplet . Translocates to the nucleus when sumoylated. RSAD2/viperin recruits it to the lipid droplet (By similarity). .

Isoform 1 and isoform 2 are ubiquitously expressed in all tissues examined, with isoform 1 being more strongly expressed than isoform 2.