IL2RB

Interleukin-2 receptor subunit beta ;
IL-2 receptor subunit beta ;
IL-2R subunit beta ;
IL-2RB ;
High affinity IL-2 receptor subunit beta ;
p70-75 ;
p75 ;
CD antigen CD122 ;

domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.,similarity:Belongs to the type I cytokine receptor family. Type 4 subfamily.,similarity:Contains 1 fibronectin type-III domain.,subunit:Non-covalent dimer of an alpha and a beta chains. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta chain), and a low affinity monomer (alpha chain). The high and intermediate affinity forms also associate with a gamma chain. Interacts with SHB upon interleukin stimulation. Interacts with HTLV-1 accessory protein p12I.,

protein complex assembly, anti-apoptosis, positive regulation of macromolecule metabolic process, positive regulation of gene expression, regulation of cell death, cytokine-mediated signaling pathway, regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death,macromolecular complex subunit organization, regulation of survival gene product expression, positive regulation of survival gene product expression, negative regulation of cell death, macromolecular complex assembly, protein complex biogenesis,

Cell membrane ; Single-pass type I membrane protein .