IL13RA1

Interleukin-13 receptor subunit alpha-1 ;
IL-13 receptor subunit alpha-1 ;
IL-13R subunit alpha-1 ;
IL-13R-alpha-1 ;
IL-13RA1 ;
Cancer/testis antigen 19 ;
CT19 ;
CD antigen CD213a1 ;

domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:Binds IL13 with a low affinity. Together with IL4R-alpha can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for IL4 signaling, but cannot replace the function of gamma C in allowing enhanced IL2 binding activity.,similarity:Belongs to the type I cytokine receptor family. Type 5 subfamily.,subunit:Interleukin 13 receptor is a complex of IL4R, IL13RA1, and possibly other components. Interacts with TRAF3IP1.,tissue specificity:Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells.,

regulation of immunoglobulin production, positive regulation of immunoglobulin production, positive regulation of immune system process, regulation of leukocyte activation, positive regulation of leukocyte activation, regulation of immune effector process, positive regulation of immune effector process, regulation of production of molecular mediator of immune response, positive regulation of production of molecular mediator of immune response, cell surface receptor linked signal transduction, positive regulation of cell proliferation, regulation of B cell proliferation,positive regulation of B cell proliferation, regulation of mononuclear cell proliferation, positive regulation of mononuclear cell proliferation, regulation of cell proliferation, regulation of lymphocyte proliferation, positive regulation of lymphocyte proliferation, regulation of B cell activation, regulation of cell activation, positive regulation of cell activation, positive regulation of B cell activation, regulation of lymphocyte activation, positive regulation of lymphocyte activation, regulation of leukocyte proliferation, positive regulation of leukocyte proliferation,

Membrane; Single-pass type I membrane protein.

Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells.