HNRNPD

Heterogeneous nuclear ribonucleoprotein D0 ;
hnRNP D0 ;
AU-rich element RNA-binding protein 1 ;

function:Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.,PTM:Arg-345 is dimethylated, probably to asymmetric dimethylarginine.,sequence caution:Contaminating sequence. Sequence of unknown origin in the N-terminal part.,sequence caution:Several sequence conflicts.,similarity:Contains 2 RRM (RNA recognition motif) domains.,subcellular location:Component of ribonucleosomes.,subunit:Part of a complex associated with the FOS mCRD domain and consisting of PABPC1, PAIP1, CSDE1/UNR and SYNCRIP. Interacts with IGF2BP2.,

RNA splicing, via transesterification reactions, RNA splicing, via transesterification reactions with bulged adenosine as nucleophile, nuclear mRNA splicing, via spliceosome, transcription, regulation of transcription, DNA-dependent, RNA processing, mRNA processing, RNA catabolic process, mRNA catabolic process, RNA splicing, macromolecule catabolic process, posttranscriptional regulation of gene expression, mRNA metabolic process, regulation of RNA stability,regulation of mRNA stability, RNA stabilization, cellular macromolecule catabolic process, regulation of transcription,mRNA stabilization, regulation of RNA metabolic process,

Nucleus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Cytoplasmic localization oscillates diurnally.