CDC16

Cell division cycle protein 16 homolog ;
Anaphase-promoting complex subunit 6 ;
APC6 ;
CDC16 homolog ;
CDC16Hs ;
Cyclosome subunit 6 ;

function:Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated. Phosphorylation on Ser-560 occurs specifically during mitosis.,similarity:Belongs to the APC6/CDC16 family.,similarity:Contains 7 TPR repeats.,subcellular location:Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle.,subunit:The APC/C is composed of at least 11 subunits. Interacts with PPP5C and CDC20.,

M phase of mitotic cell cycle, mitotic cell cycle, M phase, nuclear division, proteolysis, ubiquitin-dependent protein catabolic process, cell cycle, mitosis, regulation of mitosis, regulation of mitotic cell cycle, cell proliferation,macromolecule catabolic process, proteasomal protein catabolic process, regulation of cell cycle process, positive regulation of macromolecule metabolic process, negative regulation of macromolecule metabolic process, modification-dependent protein catabolic process, cell cycle process, cell cycle phase, protein catabolic process, anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, regulation of protein ubiquitination, negative regulation of protein ubiquitination, positive regulation of protein ubiquitination, regulation of protein modification process, negative regulation of protein modification process, positive regulation of protein modification process, regulation of cellular protein metabolic process, negative regulation of cellular protein metabolic process, positive regulation of cellular protein metabolic process, regulation of organelle organization, positive regulation of catalytic activity, negative regulation of catalytic activity, proteasomal ubiquitin-dependent protein catabolic process, modification-dependent macromolecule catabolic process, negative regulation of molecular function,positive regulation of molecular function, cellular protein catabolic process, cellular macromolecule catabolic process,organelle fission, positive regulation of protein metabolic process, negative regulation of protein metabolic process,cell division, regulation of ligase activity, positive regulation of ligase activity, negative regulation of ligase activity,negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle, positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle, regulation of ubiquitin-protein ligase activity, regulation of ubiquitin-protein ligase activity during mitotic cell cycle, positive regulation of ubiquitin-protein ligase activity, negative regulation of ubiquitin-protein ligase activity, proteolysis involved in cellular protein catabolic process, regulation of cell cycle,regulation of nuclear division,

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle . Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle.