HDAC3

Histone deacetylase 3 ;
HD3 ;
RPD3-2 ;
SMAP45 ;

catalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.,function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor.,PTM:Sumoylated in vitro.,similarity:Belongs to the histone deacetylase family. Type 1 subfamily.,subunit:Interacts with HDAC7 and HDAC9. Forms a heterologous complex at least with YY1. Interacts with DAXX, HDAC10 and DACH1. Found in a complex with NCOR1 and NCOR2. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with BCOR, MJD2A/JHDM3A, NRIP1, PRDM6 and SRY. Interacts with BTBD14B. Interacts with GLIS2 (By similarity). Interacts with CBFA2T3.,tissue specificity:Widely expressed.,

negative regulation of transcription from RNA polymerase II promoter, microtubule cytoskeleton organization, M phase, angiogenesis, blood vessel development, liver development, vasculature development, chromatin organization,transcription, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter,protein amino acid deacetylation, anti-apoptosis, cytoskeleton organization, microtubule-based process, cell cycle,spindle organization, regulation of mitotic cell cycle, negative regulation of biosynthetic process, negative regulation of signal transduction, regulation of specific transcription from RNA polymerase II promoter, negative regulation of specific transcription from RNA polymerase II promoter, negative regulation of macromolecule biosynthetic process,negative regulation of macromolecule metabolic process, regulation of protein kinase cascade, negative regulation of gene expression, negative regulation of cell communication, negative regulation of protein kinase cascade, regulation of myotube differentiation, negative regulation of myotube differentiation, regulation of cell death, regulation of striated muscle tissue development, negative regulation of transcription, chromatin modification, covalent chromatin modification, histone modification, histone deacetylation, cell cycle process, cell cycle phase, negative regulation of cellular biosynthetic process, negative regulation of gene-specific transcription, regulation of gene-specific transcription, response to drug, regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death, regulation of MAPKKK cascade, negative regulation of MAPKKK cascade, regulation of transcription, negative regulation of cell differentiation, negative regulation of cell cycle,negative regulation of transcription, DNA-dependent, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, regulation of JNK cascade, negative regulation of JNK cascade, blood vessel morphogenesis, negative regulation of response to stimulus, regulation of muscle development, regulation of skeletal muscle tissue development, regulation of skeletal muscle fiber development, regulation of muscle cell differentiation,negative regulation of muscle cell differentiation, regulation of striated muscle cell differentiation, negative regulation of striated muscle cell differentiation, negative regulation of nitrogen compound metabolic process, spindle assembly,regulation of RNA metabolic process, negative regulation of RNA metabolic process, chromosome organization,regulation of cell cycle, regulation of cell development, negative regulation of cell death, regulation of stress-activated protein kinase signaling pathway, negative regulation of stress-activated protein kinase signaling pathway, regulation of cellular response to stress,

Nucleus . Cytoplasm . Cytoplasm, cytosol . Colocalizes with XBP1 and AKT1 in the cytoplasm (PubMed:25190803). Predominantly expressed in the nucleus in the presence of CCAR2 (PubMed:21030595). .

Widely expressed.