GRK1

Rhodopsin kinase ;
RK ;
G protein-coupled receptor kinase 1 ;

catalytic activity:ATP + [rhodopsin] = ADP + [rhodopsin] phosphate.,disease:Defects in GRK1 are a cause of congenital stationary night blindness Oguchi type (CSNBO) [MIM:258100]; also known as Oguchi disease. Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision. CSNBO is an autosomal recessive form associated with fundus discoloration and abnormally slow dark adaptation.,function:Phosphorylates rhodopsin thereby initiating its deactivation.,online information:Retina International's Scientific Newsletter,PTM:Autophosphorylated.,PTM:Farnesylation is required for full activity.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 RGS domain.,tissue specificity:Retina and pineal gland.,

cell morphogenesis, cell morphogenesis involved in differentiation, eye development, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, apoptosis, cell surface receptor linked signal transduction, G-protein coupled receptor protein signaling pathway, sensory organ development, sensory perception, visual perception, phototransduction, phototransduction, visible light, cell death, regulation of G-protein coupled receptor protein signaling pathway, photoreceptor cell morphogenesis, response to radiation, response to light stimulus, detection of external stimulus, detection of abiotic stimulus, detection of light stimulus, detection of visible light, rhodopsin mediated phototransduction, response to abiotic stimulus, post-embryonic development, post-embryonic morphogenesis, positive regulation of phosphorus metabolic process, programmed cell death, rhodopsin mediated signaling pathway, death, phosphorylation, regulation of phosphate metabolic process, neuron differentiation, cellular component morphogenesis, regulation of phosphorylation, positive regulation of phosphorylation, photoreceptor cell development, response to drug, camera-type eye development, positive regulation of phosphate metabolic process, photoreceptor cell differentiation, protein amino acid autophosphorylation,eye morphogenesis, camera-type eye morphogenesis, neuron development, cell morphogenesis involved in neuron differentiation, neurological system process, cognition, detection of stimulus involved in sensory perception, detection of light stimulus involved in visual perception, sensory perception of light stimulus, detection of light stimulus involved in sensory perception, regulation of phosphorus metabolic process, detection of stimulus, retina development in camera-type eye, retina morphogenesis in camera-type eye, post-embryonic retina morphogenesis in camera-type eye,

Membrane ; Lipid-anchor . Cell projection, cilium, photoreceptor outer segment . Subcellular location is not affected by light or dark conditions. .

Retinal-specific. Expressed in rods and cones cells.