KRT18

Keratin, type I cytoskeletal 18 ;
Cell proliferation-inducing gene 46 protein ;
Cytokeratin-18 ;
CK-18 ;
Keratin-18 ;
K18 ;

disease:Defects in KRT18 are a cause of cryptogenic cirrhosis [MIM:215600].,function:Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.,induction:By IL-6.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,PTM:O-glycosylated at multiple sites; glycans consist of single N-acetylglucosamine residues.,PTM:Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6.,PTM:Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3, caspase-6 or caspase-7.,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins. Keratin-18 associates with keratin-8. Interacts with the thrombin-antithrombin complex (By similarity). Interacts with PNN, HCV core protein and mutated CFTR. Interacts with YWHAE, YWHAH and YWHAZ only when phosphorylated. Interacts with DNAJB6, TCHP and TRADD.,tissue specificity:Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.,

intracellular protein transport, post-Golgi vesicle-mediated transport, Golgi to plasma membrane transport, apoptosis,cell cycle, protein localization, cell death, regulation of cell death, programmed cell death, protein transport, vesicle-mediated transport, death, cytokine-mediated signaling pathway, tumor necrosis factor-mediated signaling pathway,cellular protein localization, regulation of apoptosis, Golgi to plasma membrane CFTR protein transport, Golgi to plasma membrane protein transport, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death, establishment of protein localization, intracellular transport, Golgi vesicle transport, negative regulation of cell death, cellular macromolecule localization,

Cytoplasm, perinuclear region. Nucleus, nucleolus.

Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.