TFR1

Transferrin receptor protein 1 ;
TR ;
TfR ;
TfR1 ;
Trfr ;
T9 ;
p90 ;
CD antigen CD71 ;
[Cleaved into: Transferrin receptor protein 1, serum form ;
sTfR ;
]

function:Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.,induction:Regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation.,miscellaneous:Canine and feline parvoviruses bind human and feline transferrin receptors and use these receptors to enter and infect cells.,miscellaneous:Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemia resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.,PTM:N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated.,PTM:Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation.,PTM:Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR).,similarity:Belongs to the peptidase M28 family. M28B subfamily.,similarity:Contains 1 PA (protease associated) domain.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit. Binds the HLA class II histocompatibility antigen, DR1. Interacts with SH3BP3. Interacts with Machupo arenavirus GPC.,

response to hypoxia, acute inflammatory response, cellular ion homeostasis, cellular iron ion homeostasis,endocytosis, defense response, acute-phase response, inflammatory response, aging, response to nutrient, response to wounding, response to extracellular stimulus, response to organic substance, response to inorganic substance,response to metal ion, response to iron ion, response to manganese ion, membrane invagination, membrane organization, vesicle-mediated transport, cellular homeostasis, cellular cation homeostasis, cellular di-, tri-valent inorganic cation homeostasis, response to nutrient levels, response to retinoic acid, response to vitamin A, response to vitamin, homeostatic process, response to copper ion, chemical homeostasis, ion homeostasis, di-, tri-valent inorganic cation homeostasis, iron ion homeostasis, cation homeostasis, cellular chemical homeostasis, response to oxygen levels,

Cell membrane ; Single-pass type II membrane protein . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .; [Transferrin receptor protein 1, serum form]: Secreted .