PRKCE

Protein kinase C epsilon type ;
nPKC-epsilon ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,domain:The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.,enzyme regulation:Three specific sites; Thr-566 (activation loop of the kinase domain), Thr-710 (turn motif) and Ser-729 (hydrophobic region), need to be phosphorylated for its full activation.,function:PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.,function:This is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme.,PTM:Phosphorylation on Thr-566 by PDPK1 triggers autophosphorylation on Ser-729.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 C2 domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 phorbol-ester/DAG-type zinc fingers.,subunit:Forms a ternary complex with TRIM63 and GN2BL1.,

regulation of protein amino acid phosphorylation, protein amino acid phosphorylation, phosphorus metabolic process,phosphate metabolic process, induction of apoptosis, intracellular signaling cascade, regulation of cell death, positive regulation of cell death, induction of programmed cell death, phosphorylation, regulation of phosphate metabolic process, regulation of protein modification process, regulation of cellular protein metabolic process, regulation of phosphorylation, regulation of apoptosis, positive regulation of apoptosis, regulation of programmed cell death,positive regulation of programmed cell death, regulation of peptidyl-tyrosine phosphorylation, regulation of phosphorus metabolic process,

Cytoplasm . Cytoplasm, cytoskeleton . Cell membrane . Cytoplasm, perinuclear region . Nucleus . Translocated to plasma membrane in epithelial cells stimulated by HGF (PubMed:17603037). Associated with the Golgi at the perinuclear site in pre-passage fibroblasts (By similarity). In passaging cells, translocated to the cell periphery (By similarity). Translocated to the nucleus in PMA-treated cells (By similarity). .

Expressed in cumulus cells (at protein level).