ALOX5

Arachidonate 5-lipoxygenase ;
5-LO ;
5-lipoxygenase ;

catalytic activity:Arachidonate + O(2) = leukotriene A(4) + H(2)O.,cofactor:Binds 1 iron ion per subunit.,cofactor:Binds 2 calcium ions per subunit.,function:Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.,pathway:Lipid metabolism; leukotriene A4 biosynthesis.,PTM:Serine phosphorylation by MAPKAPK2 is stimulated by arachidonic acid. Phosphorylation on Ser-523 by PKA has an inhibitory effect. Phosphorylation on Ser-272 prevents export from the nucleus.,similarity:Belongs to the lipoxygenase family.,similarity:Contains 1 lipoxygenase domain.,similarity:Contains 1 PLAT domain.,subcellular location:Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association.,subunit:Interacts with ALOX5AP and LTC4S.,

very-long-chain fatty acid metabolic process, fatty acid metabolic process, fatty acid biosynthetic process, unsaturated fatty acid biosynthetic process, icosanoid metabolic process, leukotriene metabolic process, defense response,inflammatory response, response to nutrient, lipid biosynthetic process, response to wounding, response to extracellular stimulus, organic acid biosynthetic process, regulation of vasoconstriction, leukotriene biosynthetic process, response to nutrient levels, unsaturated fatty acid metabolic process, cellular alkene metabolic process,alkene biosynthetic process, regulation of system process, positive regulation of vasoconstriction, carboxylic acid biosynthetic process, icosanoid biosynthetic process, positive regulation of multicellular organismal process, oxidation reduction,

Cytoplasm . Nucleus matrix . Nucleus membrane ; Peripheral membrane protein . Cytoplasm, perinuclear region . Cytoplasm, cytosol . Nucleus envelope . Nucleus intermembrane space . Shuttles between cytoplasm and nucleus (PubMed:19233132). Found exclusively in the nucleus, when phosphorylated on Ser-272 (PubMed:18978352). Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association (PubMed:19233132, PubMed:3118366, PubMed:8245774, PubMed:16275640). .