PFKFB2 (Phospho Ser483) Cell-Based Colorimetric ELISA Kit
-KA1393C
主要信息
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
Phospho
详细信息
储存
2-8°C/6 months
修饰
Phospho
检测方法
Colorimetric
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抗原&靶点信息
基因名称:
PFKFB2
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别名:
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 ;
6PF-2-K/Fru-2,6-P2ase 2 ;
PFK/FBPase 2 ;
6PF-2-K/Fru-2,6-P2ase heart-type isozyme ;
[Includes: 6-phosphofructo-2-kinase ;
Fructose-2,6-bisphosphatase ;
]
6PF-2-K/Fru-2,6-P2ase 2 ;
PFK/FBPase 2 ;
6PF-2-K/Fru-2,6-P2ase heart-type isozyme ;
[Includes: 6-phosphofructo-2-kinase ;
Fructose-2,6-bisphosphatase ;
]
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背景:
The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
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功能:
Catalytic activity:ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate.,Catalytic activity:Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.,enzyme regulation:Phosphorylation results in the activation of the kinase activity.,Function:Synthesis and degradation of fructose 2,6-bisphosphate.,similarity:In the C-terminal section; belongs to the phosphoglycerate mutase family.,subunit:Homodimer.,tissue specificity:Heart.,
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组织表达:
Heart.
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