CDC25A

M-phase inducer phosphatase 3 ;
Dual specificity phosphatase Cdc25C ;

catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,developmental stage:Expressed predominantly in G2 phase.,function:Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDC2 and activate its kinase activity.,PTM:Phosphorylated by CHK1 on Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase.,similarity:Belongs to the MPI phosphatase family.,similarity:Contains 1 rhodanese domain.,subunit:Interacts with HIV-1 Vpr, thereby inactivating CDC25C phosphatase activity.,

regulation of cyclin-dependent protein kinase activity, G1 phase of mitotic cell cycle, M phase of mitotic cell cycle,mitotic cell cycle, M phase, nuclear division, DNA metabolic process, DNA replication, protein amino acid dephosphorylation, phosphorus metabolic process, phosphate metabolic process, cell cycle, mitosis, regulation of mitosis, traversing start control point of mitotic cell cycle, regulation of mitotic cell cycle, cell proliferation, regulation of cell cycle process, dephosphorylation, regulation of phosphate metabolic process, cell cycle process, cell cycle phase,regulation of organelle organization, regulation of phosphorylation, regulation of kinase activity, regulation of protein kinase activity, organelle fission, regulation of phosphorus metabolic process, cell division, G1 phase, interphase,interphase of mitotic cell cycle, regulation of transferase activity, regulation of cell cycle, regulation of nuclear division,

Nucleus .