ATP-Citrate Lyase (Phospho Ser454) Cell-Based Colorimetric ELISA Kit
-KA1356C
主要信息
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
Phospho
详细信息
储存
2-8°C/6 months
修饰
Phospho
检测方法
Colorimetric
相关产品
Primary Antibodies
ATP-citrate Lyase Rabbit pAb
YT0415
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Primary Antibodies
ATP-citrate Lyase (Phospho Ser455) Rabbit pAb
YP0686
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ELISA Kits
Total ATP-Citrate Lyase Cell-Based Colorimetric ELISA Kit
KA4003C
预览→
ELISA Kits
ATP-Citrate Lyase (Phospho Ser454) Cell-Based Colorimetric ELISA Kit
KA1356C
预览→
抗原&靶点信息
基因名称:
ACLY
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别名:
ATP-citrate synthase ;
ATP-citrate ;
pro-S- ;
-lyase ;
ACL ;
Citrate cleavage enzyme ;
ATP-citrate ;
pro-S- ;
-lyase ;
ACL ;
Citrate cleavage enzyme ;
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背景:
ATP citrate lyase(ACLY) Homo sapiens ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014],
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功能:
Catalytic activity:ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA.,Function:ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.,similarity:In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.,similarity:In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.,subunit:Homotetramer.,
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细胞定位:
Cytoplasm, cytosol .
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