TH

P04177 tyrosine hydroxylase(Th) Rattus norvegicus catalytic activity:L-tyrosine + tetrahydrobiopterin + O(2) = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin.,cofactor:Fe(2+) ion.,enzyme regulation:Phosphorylation leads to an increase in the catalytic activity.,function:Plays an important role in the physiology of adrenergic neurons.,pathway:Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2.,PTM:In vitro, phosphorylation of Ser-19 increases the rate of Ser-40 phosphorylation, which results in enzyme opening and activation.,similarity:Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.,subunit:Homotetramer.,

regulation of neurotransmitter levels, eye development, response to hypoxia, eye photoreceptor cell differentiation,synaptic transmission, dopaminergic, protein complex assembly, tyrosine metabolic process, cellular amino acid derivative metabolic process, biogenic amine metabolic process, catecholamine metabolic process, dopamine biosynthetic process from tyrosine, cell-cell signaling, synaptic transmission, nerve-nerve synaptic transmission,sensory organ development, heart development, sensory perception, visual perception, behavior, learning or memory,learning, memory, mating behavior, mating, locomotory behavior, feeding behavior, regulation of heart contraction,aromatic amino acid family metabolic process, amine biosynthetic process, catechol metabolic process, response to endogenous stimulus, response to hormone stimulus, response to organic substance, phenol metabolic process,reproductive behavior, transmission of nerve impulse, neuron differentiation, embryonic camera-type eye development, diol metabolic process, neurotransmitter metabolic process, neurotransmitter biosynthetic process,cellular amino acid derivative biosynthetic process, biogenic amine biosynthetic process, epinephrine metabolic process, norepinephrine metabolic process, dopamine biosynthetic process, dopamine metabolic process, epinephrine biosynthetic process, norepinephrine biosynthetic process, catecholamine biosynthetic process, photoreceptor cell development, eye photoreceptor cell development, eating behavior, camera-type eye development, macromolecular complex subunit organization, regulation of system process, nitrogen compound biosynthetic process, response to ethanol, photoreceptor cell differentiation, embryonic eye morphogenesis, response to steroid hormone stimulus,embryonic organ morphogenesis, embryonic organ development, eye morphogenesis, camera-type eye morphogenesis, embryonic camera-type eye morphogenesis, embryonic morphogenesis, neuron development,neurological system process, cognition, sensory perception of light stimulus, protein oligomerization, protein homooligomerization, protein tetramerization, protein homotetramerization, behavioral interaction between organisms, oxidation reduction, macromolecular complex assembly, protein complex biogenesis, response to oxygen levels,