SYK

Tyrosine-protein kinase SYK ;
Spleen tyrosine kinase ;
p72-Syk ;

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-348 and Tyr-352. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion.,PTM:Autophosphorylated.,PTM:Phosphorylation on Tyr-323 creates a binding site for c-Cbl, an adapter protein that serves as a negative regulator of BCR-stimulated calcium ion signaling.,PTM:Phosphorylation on Tyr-348 and Tyr-352 enhances the phosphorylation and activation of phospholipase C-gamma and the early phase of calcium ion mobilization via a phosphoinositide 3-kinase-independent pathway.,PTM:Ubiquitinated by CBLB after BCR activation; which promotes proteasomal degradation.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 SH2 domains.,subunit:Interacts with CBL and SLA when it is phosphorylated. The interaction with SLA may link it to CBL, leading to its destruction. Interacts with phosphorylated NFAM1 (By similarity). Interacts with Epstein-Barr virus LMP2A. Interacts through its SH2 domains with the phosphorylated ITAM domain of CD79A which stimulates SYK autophosphorylation and activation. Interacts with FCRL3.,

MAPKKK cascade, activation of MAPK activity, cell activation, regulation of cytokine production, serotonin secretion,regulation of protein amino acid phosphorylation, positive regulation of protein amino acid phosphorylation, activation of immune response, immune response-activating cell surface receptor signaling pathway, immune system development, leukocyte differentiation, positive regulation of immune system process, regulation of leukocyte activation, positive regulation of leukocyte activation, regulation of immune effector process, positive regulation of immune effector process, regulation of leukocyte mediated immunity, immune response-activating signal transduction,immune response-regulating signal transduction, immune response-regulating cell surface receptor signaling pathway,regulation of myeloid leukocyte mediated immunity, generation of a signal involved in cell-cell signaling, protein complex assembly, protein amino acid phosphorylation, fatty acid metabolic process, fatty acid biosynthetic process,unsaturated fatty acid biosynthetic process, icosanoid metabolic process, leukotriene metabolic process, phosphorus metabolic process, phosphate metabolic process, serotonin transport, cell motion, chemotaxis, cell adhesion,leukocyte adhesion, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, integrin-mediated signaling pathway, intracellular signaling cascade, protein kinase cascade, JNK cascade,activation of JUN kinase activity, cell-cell signaling, behavior, locomotory behavior, cell proliferation, positive regulation of cell proliferation, lipid biosynthetic process, positive regulation of biosynthetic process, positive regulation of signal transduction, positive regulation of macromolecule biosynthetic process, positive regulation of phosphorus metabolic process, positive regulation of macromolecule metabolic process, regulation of protein kinase cascade, positive regulation of cell communication, amine transport, monoamine transport, organic acid biosynthetic process,phosphorylation, cell-cell adhesion, cell migration, regulation of exocytosis, peptidyl-tyrosine phosphorylation,peptidyl-tyrosine modification, regulation of phosphate metabolic process, leukotriene biosynthetic process, biological adhesion, hemopoiesis, lymphocyte differentiation, T cell differentiation, neutrophil chemotaxis, leukocyte chemotaxis,stress-activated protein kinase signaling pathway, positive regulation of cellular biosynthetic process, regulation of protein modification process, positive regulation of protein modification process, regulation of cellular protein metabolic process, positive regulation of cellular protein metabolic process, regulation of granulocyte macrophage colony-stimulating factor production, regulation of interleukin-3 production, secretion by cell, regulation of mononuclear cell proliferation, positive regulation of mononuclear cell proliferation, regulation of mast cell activation, positive regulation of mast cell activation, cellular response to stress, unsaturated fatty acid metabolic process, positive regulation of kinase activity, regulation of cytokine biosynthetic process, positive regulation of T cell proliferation, positive regulation of cytokine biosynthetic process, T cell activation, regulation of cell proliferation, regulation of T cell proliferation,regulation of phosphorylation, positive regulation of phosphorylation, taxis, positive regulation of catalytic activity,regulation of leukocyte degranulation, positive regulation of leukocyte degranulation, regulation of mast cell degranulation, positive regulation of mast cell degranulation, beta selection, regulation of MAP kinase activity, positive regulation of MAP kinase activity, regulation of MAPKKK cascade, cellular alkene metabolic process, alkene biosynthetic process, regulation of JUN kinase activity, positive regulation of JUN kinase activity, regulation of kinase activity,macromolecular complex subunit organization, positive regulation of molecular function, T cell selection, leukocyte activation, regulation of interleukin-3 biosynthetic process, positive regulation of interleukin-3 biosynthetic process,regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, regulation of B cell differentiation, positive regulation of B cell differentiation, regulation of T cell differentiation, positive regulation of T cell differentiation,regulation of gamma-delta T cell differentiation, positive regulation of gamma-delta T cell differentiation, positive regulation of cell differentiation, regulation of lymphocyte differentiation, positive regulation of lymphocyte differentiation, regulation of protein kinase activity, positive regulation of protein kinase activity, positive regulation of exocytosis, positive regulation of phosphate metabolic process, regulation of JNK cascade, carboxylic acid biosynthetic process, icosanoid biosynthetic process, alpha-beta T cell activation, alpha-beta T cell differentiation, regulation of alpha-beta T cell activation, positive regulation of alpha-beta T cell activation, regulation of alpha-beta T cell differentiation, positive regulation of alpha-beta T cell differentiation, regulation of alpha-beta T cell proliferation,positive regulation of alpha-beta T cell proliferation, regulation of gamma-delta T cell activation, positive regulation of gamma-delta T cell activation, lymphocyte activation, protein amino acid autophosphorylation, secretion, hemopoietic or lymphoid organ development, positive regulation of response to stimulus, cell motility, regulation of lymphocyte proliferation, positive regulation of lymphocyte proliferation, regulation of peptidyl-tyrosine phosphorylation, positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of immune response, regulation of calcium-mediated signaling, positive regulation of calcium-mediated signaling, antigen receptor-mediated signaling pathway, B cell receptor signaling pathway, regulation of T cell activation, regulation of B cell activation, regulation of cell activation, positive regulation of cell activation, positive regulation of T cell activation, positive regulation of B cell activation, leukocyte migration, regulation of secretion, positive regulation of secretion, positive regulation of transport, positive regulation of developmental process, regulation of phosphorus metabolic process, positive regulation of protein metabolic process, regulation of lymphocyte activation, positive regulation of lymphocyte activation, regulation of transferase activity, positive regulation of transferase activity, localization of cell, cell chemotaxis, regulation of cellular localization, regulation of vesicle-mediated transport, macromolecular complex assembly, protein complex biogenesis, regulation of stress-activated protein kinase signaling pathway, regulation of leukocyte proliferation, positive regulation of leukocyte proliferation, regulation of cellular response to stress,

Cell membrane . Cytoplasm, cytosol .

Widely expressed in hematopoietic cells (at protein level) (PubMed:8163536). Expressed in neutrophils (at protein level) (PubMed:15123770). Within the B-cell compartment, expressed from pro- and pre-B cells to plasma cells (PubMed:8163536).