PAK1/PAK2/PAK3

MAPKKK cascade, regulation of protein amino acid phosphorylation, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, apoptosis, ER-nuclear signaling pathway, cytoskeleton organization,intracellular signaling cascade, protein kinase cascade, cell death, regulation of protein kinase cascade, programmed cell death, death, phosphorylation, regulation of phosphate metabolic process, regulation of protein modification process, regulation of cellular protein metabolic process, positive regulation of kinase activity, regulation of phosphorylation, positive regulation of catalytic activity, regulation of MAP kinase activity, positive regulation of MAP kinase activity, regulation of MAPKKK cascade, regulation of JUN kinase activity, positive regulation of JUN kinase activity, regulation of kinase activity, positive regulation of molecular function, regulation of protein kinase activity,positive regulation of protein kinase activity, regulation of JNK cascade, protein amino acid autophosphorylation,regulation of phosphorus metabolic process, regulation of transferase activity, positive regulation of transferase activity, regulation of stress-activated protein kinase signaling pathway, regulation of cellular response to stress,

Cytoplasm . Cell junction, focal adhesion . Cell projection, lamellipodium . Cell membrane . Cell projection, ruffle membrane . Cell projection, invadopodium . Nucleus, nucleoplasm . Chromosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Colocalizes with RUFY3, F-actin and other core migration components in invadopodia at the cell periphery (PubMed:25766321). Recruited to the cell membrane by interaction with CDC42 and RAC1. Recruited to focal adhesions upon activation. Colocalized with CIB1 within membrane ruffles during cell spreading upon readhesion to fibronectin. Upon DNA damage, translocates to the nucleoplasm when phosphorylated at Thr-212 where is co-recruited with MORC2 on damaged chromatin (PubMed:23260667). Localization to the centrosome does not depend upon the presence of gamma-tubulin (PubMed:27012601). Localization of the active, but not inactive, protein to the adhesions and edge of lamellipodia is mediated by interaction with GIT1 (PubMed:11896197). .

Overexpressed in gastric cancer cells and tissues (at protein level) (PubMed:25766321).