ADRBK1

Beta-adrenergic receptor kinase 1 ;
Beta-ARK-1 ;
G-protein coupled receptor kinase 2 ;

catalytic activity:ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate.,catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them.,online information:Beta adrenergic receptor kinase entry,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 RGS domain.,subunit:Interacts with GIT1 (By similarity). Interacts with, and phosphorylates chemokine-stimulated CCR5.,tissue specificity:Expressed in peripheral blood leukocytes.,

response to reactive oxygen species, regulation of the force of heart contraction, desensitization of G-protein coupled receptor protein signaling pathway, muscle system process, circulatory system process, heart process, regulation of the force of heart contraction by chemical signal, negative regulation of the force of heart contraction by chemical signal, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, muscle contraction, regulation of muscle contraction, striated muscle contraction, regulation of striated muscle contraction,response to oxidative stress, cell surface receptor linked signal transduction, G-protein coupled receptor protein signaling pathway, muscarinic acetylcholine receptor signaling pathway, tachykinin receptor signaling pathway, heart development, aging, blood circulation, regulation of heart contraction, regulation of G-protein coupled receptor protein signaling pathway, negative regulation of signal transduction, response to organic substance, response to inorganic substance, negative regulation of cell communication, response to organic cyclic substance, phosphorylation, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, peptidyl-serine modification, peptidyl-threonine modification, adaptation of signaling pathway, positive regulation of catecholamine secretion, response to hydrogen peroxide, regulation of system process, negative regulation of G-protein coupled receptor protein signaling pathway,negative regulation of heart contraction, negative regulation of muscle contraction, negative regulation of striated muscle contraction, regulation of catecholamine secretion, regulation of secretion, positive regulation of secretion,positive regulation of transport, negative regulation of multicellular organismal process, regulation of amine transport,positive regulation of amine transport, heart contraction, cardiac muscle contraction, regulation of cellular localization,

Cytoplasm . Cell membrane . Cell junction, synapse, postsynapse . Cell junction, synapse, presynapse .

Expressed in peripheral blood leukocytes.