ETS1

Protein C-ets-1 ;
p54 ;

disease:ETS is responsible for erythroblast and fibroblast transformation. The juxtaposition of the interferon and c-ETS-1 proto-oncogene may be involved in the pathogenesis of human monocytic leukemia.,function:Transcription factor.,PTM:Sumoylated on Lys-15 and Lys-227, preferentially by SUMO2; which inhibits transcriptional activity.,PTM:Ubiquitinated; which induces proteasomal degradation.,similarity:Belongs to the ETS family.,similarity:Contains 1 ETS DNA-binding domain.,similarity:Contains 1 PNT (pointed) domain.,subunit:Interacts with MAF and MAFB (By similarity). Binds to DAXX. Interacts with UBE2I.,

transcription, transcription, DNA-dependent, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter, induction of apoptosis, cell motion,immune response, nucleus organization, negative regulation of cell proliferation, positive regulation of biosynthetic process, regulation of specific transcription from RNA polymerase II promoter, positive regulation of specific transcription from RNA polymerase II promoter, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, positive regulation of gene expression, regulation of cell death,positive regulation of cell death, induction of programmed cell death, nuclear body organization, PML body organization, positive regulation of cellular biosynthetic process, regulation of gene-specific transcription, RNA biosynthetic process, regulation of homeostatic process, regulation of cell proliferation, regulation of apoptosis,positive regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death,positive regulation of gene-specific transcription, regulation of transcription, positive regulation of cell differentiation,regulation of myeloid cell differentiation, positive regulation of myeloid cell differentiation, regulation of erythrocyte differentiation, positive regulation of erythrocyte differentiation, negative regulation of cell cycle, positive regulation of transcription, DNA-dependent, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter,response to antibiotic, cell motility, positive regulation of developmental process, positive regulation of nitrogen compound metabolic process, regulation of RNA metabolic process, positive regulation of RNA metabolic process,regulation of cell motion, positive regulation of cell motion, localization of cell, regulation of cell cycle,

Cytoplasm . Nucleus . Delocalizes from nucleus to cytoplasm when coexpressed with isoform Ets-1 p27. .

Highly expressed within lymphoid cells. Isoforms c-ETS-1A and Ets-1 p27 are both detected in all fetal tissues tested, but vary with tissue type in adult tissues. None is detected in brain or kidney.