Akt1 S1 (Phospho Thr246) Cell-Based Colorimetric ELISA Kit
-KA1267C
主要信息
Target
Akt1 S1
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
Phospho
详细信息
储存
2-8°C/6 months
修饰
Phospho
检测方法
Colorimetric
相关产品
Primary Antibodies
PRAS40 Rabbit pAb
YT3850
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Primary Antibodies
PRAS40 (Phospho Thr246) Rabbit pAb
YP0302
预览→
ELISA Kits
Total PRAS40 Cell-Based Colorimetric ELISA Kit
KA3016C
预览→
ELISA Kits
Akt1 S1 (Phospho Thr246) Cell-Based Colorimetric ELISA Kit
KA1267C
预览→
抗原&靶点信息
基因名称:
AKT1S1;PRAS40
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蛋白名称:
Proline-rich AKT1 substrate 1;40 kDa proline-rich AKT substrate;
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背景:
AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 [PubMed 12524439]).[supplied by OMIM, Mar 2008]
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功能:
Negative regulator of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (By similarity).In absence of insulin and nutrients, AKT1S1 associates with the mTORC1 complex and directly inhibits mTORC1 activity by blocking the MTOR substrate-recruitment site (By similarity).In response to insulin and nutrients, AKT1S1 dissociates from mTORC1 (By similarity).Its activity is dependent on its phosphorylation state and binding to 14-3-3 (By similarity).May also play a role in nerve growth factor-mediated neuroprotection (PubMed:14973226, PubMed:16397181).
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细胞定位:
Cytoplasm > cytosol. Found in the cytosolic fraction of the brain.
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组织表达:
Widely expressed with highest levels of expression in liver and heart. Expressed at higher levels in cancer cell lines (e.g. A-549 and HeLa) than in normal cell lines (e.g. HEK293).
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信号通路
Cellular Processes >> Transport and catabolism >> Autophagy - animal
Organismal Systems >> Aging >> Longevity regulating pathway
Organismal Systems >> Aging >> Longevity regulating pathway - multiple species
Environmental Information Processing >> Signal transduction >> AMPK signaling pathway
Environmental Information Processing >> Signal transduction >> mTOR signaling pathway
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